A homeobox gene essential for zebrafish notochord development

William S. Talbot, Bill Trevarrow, Marnie E. Halpern, Anna E. Melby, Gist Farr, John H. Postlethwait, Trevor Jowett, Charles B. kimmel, David Kimelman

Research output: Contribution to journalArticlepeer-review

Abstract

The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalNature
Volume378
Issue number6553
DOIs
StatePublished - Nov 9 1995
Externally publishedYes

ASJC Scopus subject areas

  • General

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