A homeobox gene essential for zebrafish notochord development

William S. Talbot, Bill Trevarrow, Marnie Halpern, Anna E. Melby, Gist Farr, John H. Postlethwait, Trevor Jowett, Charles B. Kimmel, David Kimelman

Research output: Contribution to journalArticle

Abstract

The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalNature
Volume378
Issue number6553
DOIs
StatePublished - Nov 9 1995
Externally publishedYes

Fingerprint

Notochord
Homeobox Genes
Zebrafish
Head
Amphibians
Vertebrates
Embryonic Structures

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Talbot, W. S., Trevarrow, B., Halpern, M., Melby, A. E., Farr, G., Postlethwait, J. H., ... Kimelman, D. (1995). A homeobox gene essential for zebrafish notochord development. Nature, 378(6553), 145-149. https://doi.org/10.1038/378150a0

A homeobox gene essential for zebrafish notochord development. / Talbot, William S.; Trevarrow, Bill; Halpern, Marnie; Melby, Anna E.; Farr, Gist; Postlethwait, John H.; Jowett, Trevor; Kimmel, Charles B.; Kimelman, David.

In: Nature, Vol. 378, No. 6553, 09.11.1995, p. 145-149.

Research output: Contribution to journalArticle

Talbot, WS, Trevarrow, B, Halpern, M, Melby, AE, Farr, G, Postlethwait, JH, Jowett, T, Kimmel, CB & Kimelman, D 1995, 'A homeobox gene essential for zebrafish notochord development', Nature, vol. 378, no. 6553, pp. 145-149. https://doi.org/10.1038/378150a0
Talbot WS, Trevarrow B, Halpern M, Melby AE, Farr G, Postlethwait JH et al. A homeobox gene essential for zebrafish notochord development. Nature. 1995 Nov 9;378(6553):145-149. https://doi.org/10.1038/378150a0
Talbot, William S. ; Trevarrow, Bill ; Halpern, Marnie ; Melby, Anna E. ; Farr, Gist ; Postlethwait, John H. ; Jowett, Trevor ; Kimmel, Charles B. ; Kimelman, David. / A homeobox gene essential for zebrafish notochord development. In: Nature. 1995 ; Vol. 378, No. 6553. pp. 145-149.
@article{62e4fb9475ef44a9ac2e6789e9490c30,
title = "A homeobox gene essential for zebrafish notochord development",
abstract = "The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.",
author = "Talbot, {William S.} and Bill Trevarrow and Marnie Halpern and Melby, {Anna E.} and Gist Farr and Postlethwait, {John H.} and Trevor Jowett and Kimmel, {Charles B.} and David Kimelman",
year = "1995",
month = "11",
day = "9",
doi = "10.1038/378150a0",
language = "English (US)",
volume = "378",
pages = "145--149",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6553",

}

TY - JOUR

T1 - A homeobox gene essential for zebrafish notochord development

AU - Talbot, William S.

AU - Trevarrow, Bill

AU - Halpern, Marnie

AU - Melby, Anna E.

AU - Farr, Gist

AU - Postlethwait, John H.

AU - Jowett, Trevor

AU - Kimmel, Charles B.

AU - Kimelman, David

PY - 1995/11/9

Y1 - 1995/11/9

N2 - The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

AB - The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

UR - http://www.scopus.com/inward/record.url?scp=84988045934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988045934&partnerID=8YFLogxK

U2 - 10.1038/378150a0

DO - 10.1038/378150a0

M3 - Article

C2 - 7477317

AN - SCOPUS:0028789927

VL - 378

SP - 145

EP - 149

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6553

ER -