A historical and practical review of first trimester aneuploidy screening

Melissa L. Russo; Karin J. Blakemore

doi:10.1016/j.siny.2013.11.013

A historical and practical review of first trimester aneuploidy screening

Melissa L. Russo, Karin J. Blakemore

School of Medicine

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

There have been tremendous advancements over the past three decades in prenatal screening for aneuploidy and we have changed our practice from screening by maternal age alone to 'combined' first trimester screening and circulating cell-free fetal DNA. We currently use the nuchal translucency and biochemical markers of free β-hCG and PAPP-A to determine the risk of fetal aneuploidy. The primary goal is to identify higher risk women for fetal aneuploidy early in pregnancy and give them the option to pursue invasive testing in a timely manner if desired.

Original language	English (US)
Pages (from-to)	183-187
Number of pages	5
Journal	Seminars in Fetal and Neonatal Medicine
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.siny.2013.11.013
State	Published - Jun 2014

Keywords

Aneuploidy
First trimester screening
Free β-human chorionic gonadotropin
Maternal serum screening tests
Nuchal translucency measurement
Pregnancy-associated plasma protein A

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.siny.2013.11.013

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abstract = "There have been tremendous advancements over the past three decades in prenatal screening for aneuploidy and we have changed our practice from screening by maternal age alone to 'combined' first trimester screening and circulating cell-free fetal DNA. We currently use the nuchal translucency and biochemical markers of free β-hCG and PAPP-A to determine the risk of fetal aneuploidy. The primary goal is to identify higher risk women for fetal aneuploidy early in pregnancy and give them the option to pursue invasive testing in a timely manner if desired.",

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KW - Nuchal translucency measurement

KW - Pregnancy-associated plasma protein A

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A historical and practical review of first trimester aneuploidy screening

Abstract

Keywords

ASJC Scopus subject areas

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