A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

Zhijiang Yan, Mathieu Delannoy, Chen Ling, Danielle Daee, Fekret Osman, Parameswary A. Muniandy, Xi Shen, Anneke B. Oostra, Hansen Du, Jurgen Steltenpool, Ti Lin, Beatrice Schuster, Chantal Décaillet, Andrzej Stasiak, Alicja Z. Stasiak, Stacie Stone, Maureen E. Hoatlin, Detlev Schindler, Christopher L. Woodcock, Hans JoenjeRanjan Sen, Johan P. de Winter, Lei Li, Michael M. Seidman, Matthew C. Whitby, Kyungjae Myung, Angelos Constantinou, Weidong Wang

Research output: Contribution to journalArticle

Abstract

FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. We find that MHF stimulates DNA binding and replication fork remodeling by FANCM. In the cell, FANCM and MHF are rapidly recruited to forks stalled by DNA interstrand crosslinks, and both are required for cellular resistance to such lesions. In vertebrates, FANCM-MHF associates with the Fanconi anemia (FA) core complex, promotes FANCD2 monoubiquitination in response to DNA damage, and suppresses sister-chromatid exchanges. Yeast orthologs of these proteins function together to resist MMS-induced DNA damage and promote gene conversion at blocked replication forks. Thus, FANCM-MHF is an essential DNA-remodeling complex that protects replication forks from yeast to human.

Original languageEnglish (US)
Pages (from-to)865-878
Number of pages14
JournalMolecular Cell
Volume37
Issue number6
DOIs
StatePublished - Mar 26 2010
Externally publishedYes

Fingerprint

Genomic Instability
Histones
DNA
DNA Replication
DNA Damage
Fanconi Anemia
Gene Conversion
Sister Chromatid Exchange
Fungal Proteins
Vertebrates
Yeasts

Keywords

  • DNA
  • PROTEINS

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Yan, Z., Delannoy, M., Ling, C., Daee, D., Osman, F., Muniandy, P. A., ... Wang, W. (2010). A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability. Molecular Cell, 37(6), 865-878. https://doi.org/10.1016/j.molcel.2010.01.039

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability. / Yan, Zhijiang; Delannoy, Mathieu; Ling, Chen; Daee, Danielle; Osman, Fekret; Muniandy, Parameswary A.; Shen, Xi; Oostra, Anneke B.; Du, Hansen; Steltenpool, Jurgen; Lin, Ti; Schuster, Beatrice; Décaillet, Chantal; Stasiak, Andrzej; Stasiak, Alicja Z.; Stone, Stacie; Hoatlin, Maureen E.; Schindler, Detlev; Woodcock, Christopher L.; Joenje, Hans; Sen, Ranjan; de Winter, Johan P.; Li, Lei; Seidman, Michael M.; Whitby, Matthew C.; Myung, Kyungjae; Constantinou, Angelos; Wang, Weidong.

In: Molecular Cell, Vol. 37, No. 6, 26.03.2010, p. 865-878.

Research output: Contribution to journalArticle

Yan, Z, Delannoy, M, Ling, C, Daee, D, Osman, F, Muniandy, PA, Shen, X, Oostra, AB, Du, H, Steltenpool, J, Lin, T, Schuster, B, Décaillet, C, Stasiak, A, Stasiak, AZ, Stone, S, Hoatlin, ME, Schindler, D, Woodcock, CL, Joenje, H, Sen, R, de Winter, JP, Li, L, Seidman, MM, Whitby, MC, Myung, K, Constantinou, A & Wang, W 2010, 'A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability', Molecular Cell, vol. 37, no. 6, pp. 865-878. https://doi.org/10.1016/j.molcel.2010.01.039
Yan, Zhijiang ; Delannoy, Mathieu ; Ling, Chen ; Daee, Danielle ; Osman, Fekret ; Muniandy, Parameswary A. ; Shen, Xi ; Oostra, Anneke B. ; Du, Hansen ; Steltenpool, Jurgen ; Lin, Ti ; Schuster, Beatrice ; Décaillet, Chantal ; Stasiak, Andrzej ; Stasiak, Alicja Z. ; Stone, Stacie ; Hoatlin, Maureen E. ; Schindler, Detlev ; Woodcock, Christopher L. ; Joenje, Hans ; Sen, Ranjan ; de Winter, Johan P. ; Li, Lei ; Seidman, Michael M. ; Whitby, Matthew C. ; Myung, Kyungjae ; Constantinou, Angelos ; Wang, Weidong. / A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability. In: Molecular Cell. 2010 ; Vol. 37, No. 6. pp. 865-878.
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