A histochemical study of the fibrinolytic activity in dermal tuberculous lesions produced by BCG in rabbits

Athanasios Smokovitis, Mineharu Sugimoto, Arthur M. Dannenberg, Tage Astrup

Research output: Contribution to journalArticle

Abstract

Dermal tuberculous lesions were produced in rabbits by the injection of BCG, the vaccine strain of the tubercle Bacillus. The lesions showed a remarkable increase of focal fibrinolytic activity throughout a 4- to 53-day period of growth and regression. The fibrinolytic activity was caused by a plasminogen activator. At 11 to 18 days, when hypersensitivity to the BCG vaccine became pronounced and caseous centers developed, fibrinolytic activity was particularly high. It was mainly related to dilated small blood vessels and to new capillaries in the granulation tissue. In the deep dermis near the lesion, dilated larger blood vessels showed increased fibrinolytic activity during the late stages of the healing process. Dilated larger blood vessels in the deep dermis between the lesion area and the normal skin frequently showed increased activity independent of the age of the lesion.

Original languageEnglish (US)
Pages (from-to)236-241
Number of pages6
JournalExperimental and Molecular Pathology
Volume25
Issue number2
DOIs
StatePublished - Oct 1976

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

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