TY - JOUR
T1 - A histochemical study of the fibrinolytic activity in dermal tuberculous lesions produced by BCG in rabbits
AU - Smokovitis, Athanasios
AU - Sugimoto, Mineharu
AU - Dannenberg, Arthur M.
AU - Astrup, Tage
N1 - Funding Information:
1 This study was supported by USPHS Grants HL-05020 and HE-14153 from the National Heart and Lung Institute, and by USPHS Grant AI-08876 from the National Institute Allergy and Infectious Diseases. Part of the experimental work was performed at the Institute for Medical Research of the James F. Mitchell Foundation, Washington, D.C. 31 5 At Johns Hopkins University on leave of absence from the Department Kumamoto University School of Medicine, Kumamoto, Japan. G To whom all correspondence should addressed.
PY - 1976/10
Y1 - 1976/10
N2 - Dermal tuberculous lesions were produced in rabbits by the injection of BCG, the vaccine strain of the tubercle Bacillus. The lesions showed a remarkable increase of focal fibrinolytic activity throughout a 4- to 53-day period of growth and regression. The fibrinolytic activity was caused by a plasminogen activator. At 11 to 18 days, when hypersensitivity to the BCG vaccine became pronounced and caseous centers developed, fibrinolytic activity was particularly high. It was mainly related to dilated small blood vessels and to new capillaries in the granulation tissue. In the deep dermis near the lesion, dilated larger blood vessels showed increased fibrinolytic activity during the late stages of the healing process. Dilated larger blood vessels in the deep dermis between the lesion area and the normal skin frequently showed increased activity independent of the age of the lesion.
AB - Dermal tuberculous lesions were produced in rabbits by the injection of BCG, the vaccine strain of the tubercle Bacillus. The lesions showed a remarkable increase of focal fibrinolytic activity throughout a 4- to 53-day period of growth and regression. The fibrinolytic activity was caused by a plasminogen activator. At 11 to 18 days, when hypersensitivity to the BCG vaccine became pronounced and caseous centers developed, fibrinolytic activity was particularly high. It was mainly related to dilated small blood vessels and to new capillaries in the granulation tissue. In the deep dermis near the lesion, dilated larger blood vessels showed increased fibrinolytic activity during the late stages of the healing process. Dilated larger blood vessels in the deep dermis between the lesion area and the normal skin frequently showed increased activity independent of the age of the lesion.
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U2 - 10.1016/0014-4800(76)90034-4
DO - 10.1016/0014-4800(76)90034-4
M3 - Article
C2 - 791667
AN - SCOPUS:0017175780
SN - 0014-4800
VL - 25
SP - 236
EP - 241
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
IS - 2
ER -