A highly immunogenic tumor transfected with a murine transforming growth factor type β1 cDNA escapes immune surveillance

Guillermo Torre-Amione, R. Daniel Beauchamp, Hartmut Koeppen, Ben H. Park, Hans Schreiber, Harold L. Moses, Donald A. Rowley

Research output: Contribution to journalArticlepeer-review

Abstract

A highly immunogenic C3H-derived UV-induced tumor was cotransfected with a murine transforming growth factor type β1 (TGF-β1) cDNA and a neomycin-resistance gene. Stable clones were isolated and used in vitro and in vivo to determine the effects of endogenously produced TGF-β on cytolytic T-lymphocyte (CTL) responses. Tumor cells producing TGF-β, though retaining expression for class I major histocompatibility complex molecules and the tumor-specific antigen, did not stimulate primary CTL responses in vitro and were not effective in vivo for directly stimulating primary CTL or in priming for CTL responses. Furthermore, TGF-β-producing tumors grew progressively in transiently immunosuppressed mice without losing the tumor antigen; thus, TGF-β produced by tumors may promote escape from immune surveillance.

Original languageEnglish (US)
Pages (from-to)1486-1490
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number4
StatePublished - 1990
Externally publishedYes

Keywords

  • Immunosuppression
  • Tumor progression

ASJC Scopus subject areas

  • Genetics
  • General

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