A highly charged voltage-sensor helix spontaneously translocates across membranes

Jing He, Kalina A Hristova, William C. Wimley

Research output: Contribution to journalArticle

Abstract

Moving freely: A recent model for voltage gating of potassium channels proposed that the four arginine residues of the voltage-sensing S4 helix (left) are in direct contact with the membrane lipids and move into the hydrocarbon core of the membrane during gating. It is demonstrated that the physical properties of the isolated S4 sequence (right) are sufficient to allow it to freely translocate across synthetic membranes.

Original languageEnglish (US)
Pages (from-to)7150-7153
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number29
DOIs
StatePublished - Jul 16 2012

Fingerprint

Membranes
Arginine
Potassium Channels
Sensors
Electric potential
Membrane Lipids
Hydrocarbons
Potassium
Physical properties

Keywords

  • Ion channels
  • Membrane proteins
  • Peptides
  • Translocation
  • Voltage sensor

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

A highly charged voltage-sensor helix spontaneously translocates across membranes. / He, Jing; Hristova, Kalina A; Wimley, William C.

In: Angewandte Chemie - International Edition, Vol. 51, No. 29, 16.07.2012, p. 7150-7153.

Research output: Contribution to journalArticle

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