A highly charged voltage-sensor helix spontaneously translocates across membranes

Jing He; Kalina Hristova; William C. Wimley

doi:10.1002/anie.201202741

A highly charged voltage-sensor helix spontaneously translocates across membranes

Jing He, Kalina Hristova, William C. Wimley

Whiting School of Engineering

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Moving freely: A recent model for voltage gating of potassium channels proposed that the four arginine residues of the voltage-sensing S4 helix (left) are in direct contact with the membrane lipids and move into the hydrocarbon core of the membrane during gating. It is demonstrated that the physical properties of the isolated S4 sequence (right) are sufficient to allow it to freely translocate across synthetic membranes.

Original language	English (US)
Pages (from-to)	7150-7153
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	29
DOIs	https://doi.org/10.1002/anie.201202741
State	Published - Jul 16 2012

Keywords

Ion channels
Membrane proteins
Peptides
Translocation
Voltage sensor

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201202741

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AU - Hristova, Kalina

AU - Wimley, William C.

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AB - Moving freely: A recent model for voltage gating of potassium channels proposed that the four arginine residues of the voltage-sensing S4 helix (left) are in direct contact with the membrane lipids and move into the hydrocarbon core of the membrane during gating. It is demonstrated that the physical properties of the isolated S4 sequence (right) are sufficient to allow it to freely translocate across synthetic membranes.

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KW - Membrane proteins

KW - Peptides

KW - Translocation

KW - Voltage sensor

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A highly charged voltage-sensor helix spontaneously translocates across membranes

Abstract

Keywords

ASJC Scopus subject areas

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