A high-performance magnetic resonance imaging T2 contrast agent

Jian Qin; Sophie Laurent; Yun Suk Jo; Alain Roch; Maria Mikhaylova; Zaver M. Bhujwalla; Robert N. Müller; Mamoun Muhammed

doi:10.1002/adma.200602326

A high-performance magnetic resonance imaging T₂ contrast agent

Jian Qin, Sophie Laurent, Yun Suk Jo, Alain Roch, Maria Mikhaylova, Zaver M. Bhujwalla, Robert N. Müller, Mamoun Muhammed

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The development of superparamagnetic iron oxide nanoparticles (SPIONs) as magnetic resonance imaging (MRI) contrast-enhancing agents with biocompatible surface coatings for biomedical applications, is reported. SPIONs were coated with a layer of oleic acids through the hydrophobic interaction, while two poly(ethylene oxide (PEO) chains solublize the particles in aqueous media due to its high hydrophilicity. The crystal structure of the SPIONs was identified by using X-ray diffraction (XRD). The magnetic properties of the iron oxide nanoparticles were analyzed at room temperature by using a vibrating sample magnetometer (VSM). Fourier-transform infrared (FTIR) spectra of SPION were also recorded to confirm the presence of a hierarchical coating layer consisting of PF127 and oleic acid on the surface of the nanoparticles. Results show that SPION exhibits high relaxivities ratio, which is important for excellent resolution.

Original language	English (US)
Pages (from-to)	1874-1878
Number of pages	5
Journal	Advanced Materials
Volume	19
Issue number	14
DOIs	https://doi.org/10.1002/adma.200602326
State	Published - Jul 16 2007

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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title = "A high-performance magnetic resonance imaging T2 contrast agent",

abstract = "The development of superparamagnetic iron oxide nanoparticles (SPIONs) as magnetic resonance imaging (MRI) contrast-enhancing agents with biocompatible surface coatings for biomedical applications, is reported. SPIONs were coated with a layer of oleic acids through the hydrophobic interaction, while two poly(ethylene oxide (PEO) chains solublize the particles in aqueous media due to its high hydrophilicity. The crystal structure of the SPIONs was identified by using X-ray diffraction (XRD). The magnetic properties of the iron oxide nanoparticles were analyzed at room temperature by using a vibrating sample magnetometer (VSM). Fourier-transform infrared (FTIR) spectra of SPION were also recorded to confirm the presence of a hierarchical coating layer consisting of PF127 and oleic acid on the surface of the nanoparticles. Results show that SPION exhibits high relaxivities ratio, which is important for excellent resolution.",

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AU - Qin, Jian

AU - Laurent, Sophie

AU - Jo, Yun Suk

AU - Roch, Alain

AU - Mikhaylova, Maria

AU - Bhujwalla, Zaver M.

AU - Müller, Robert N.

AU - Muhammed, Mamoun

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AB - The development of superparamagnetic iron oxide nanoparticles (SPIONs) as magnetic resonance imaging (MRI) contrast-enhancing agents with biocompatible surface coatings for biomedical applications, is reported. SPIONs were coated with a layer of oleic acids through the hydrophobic interaction, while two poly(ethylene oxide (PEO) chains solublize the particles in aqueous media due to its high hydrophilicity. The crystal structure of the SPIONs was identified by using X-ray diffraction (XRD). The magnetic properties of the iron oxide nanoparticles were analyzed at room temperature by using a vibrating sample magnetometer (VSM). Fourier-transform infrared (FTIR) spectra of SPION were also recorded to confirm the presence of a hierarchical coating layer consisting of PF127 and oleic acid on the surface of the nanoparticles. Results show that SPION exhibits high relaxivities ratio, which is important for excellent resolution.

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