A heterotopic primate model for facial composite tissue transplantation

Ronald P. Silverman, Nia D. Banks, Louis J. DeTolla, Steven T. Shipley, Aruna Panda, Rigoberto A. Sanchez, Agnes M. Azimzadeh, Richard N. Pierson, Donghua Wang, Eduardo D. Rodriguez, Luther H. Holton, Stephen T. Bartlett

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to develop a nonhuman primate model for heterotopic composite tissue facial transplantation in which to study the natural history of facial transplantation and evaluate immunosuppressive regimens.A composite oromandibular facial segment transplant based on the common carotid artery was evaluated. Flaps from 7 cynomolgus monkeys were transplanted to the groins of 7 recipients at the superficial femoral artery and vein. The immunosuppressive regimen consisted of thymoglobulin, rapamycin, and tacrolimus. Allograft survival ranged from 6 to 129 days. Histology performed in the long-term survivor at the time of necropsy revealed extensive inflammation and necrosis of the allograft skin; however, muscle and bone elements were viable, with minimal inflammation.This heterotopic facial transplantation model avoids the potential morbidity of mandibular resection and orthotopic facial transplantation. Our work also concurs with the work of other groups who found that the skin component is the most antigenic.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalAnnals of Plastic Surgery
Volume60
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

Fingerprint

Facial Transplantation
Tissue Transplantation
Primates
Immunosuppressive Agents
Allografts
Heterotopic Transplantation
Inflammation
Choristoma
Skin
Femoral Vein
Macaca fascicularis
Groin
Common Carotid Artery
Tacrolimus
Sirolimus
Femoral Artery
Natural History
Survivors
Histology
Necrosis

Keywords

  • Facial composite tissue allografting
  • Immune tolerance
  • Primate model

ASJC Scopus subject areas

  • Surgery

Cite this

Silverman, R. P., Banks, N. D., DeTolla, L. J., Shipley, S. T., Panda, A., Sanchez, R. A., ... Bartlett, S. T. (2008). A heterotopic primate model for facial composite tissue transplantation. Annals of Plastic Surgery, 60(2), 209-216. https://doi.org/10.1097/SAP.0b013e318061b792

A heterotopic primate model for facial composite tissue transplantation. / Silverman, Ronald P.; Banks, Nia D.; DeTolla, Louis J.; Shipley, Steven T.; Panda, Aruna; Sanchez, Rigoberto A.; Azimzadeh, Agnes M.; Pierson, Richard N.; Wang, Donghua; Rodriguez, Eduardo D.; Holton, Luther H.; Bartlett, Stephen T.

In: Annals of Plastic Surgery, Vol. 60, No. 2, 02.2008, p. 209-216.

Research output: Contribution to journalArticle

Silverman, RP, Banks, ND, DeTolla, LJ, Shipley, ST, Panda, A, Sanchez, RA, Azimzadeh, AM, Pierson, RN, Wang, D, Rodriguez, ED, Holton, LH & Bartlett, ST 2008, 'A heterotopic primate model for facial composite tissue transplantation', Annals of Plastic Surgery, vol. 60, no. 2, pp. 209-216. https://doi.org/10.1097/SAP.0b013e318061b792
Silverman RP, Banks ND, DeTolla LJ, Shipley ST, Panda A, Sanchez RA et al. A heterotopic primate model for facial composite tissue transplantation. Annals of Plastic Surgery. 2008 Feb;60(2):209-216. https://doi.org/10.1097/SAP.0b013e318061b792
Silverman, Ronald P. ; Banks, Nia D. ; DeTolla, Louis J. ; Shipley, Steven T. ; Panda, Aruna ; Sanchez, Rigoberto A. ; Azimzadeh, Agnes M. ; Pierson, Richard N. ; Wang, Donghua ; Rodriguez, Eduardo D. ; Holton, Luther H. ; Bartlett, Stephen T. / A heterotopic primate model for facial composite tissue transplantation. In: Annals of Plastic Surgery. 2008 ; Vol. 60, No. 2. pp. 209-216.
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