A helicase with an extra spring in its step

Michael Schlierf; Taekjip Ha

doi:10.1016/j.cell.2012.09.031

A helicase with an extra spring in its step

Michael Schlierf, Taekjip Ha

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.

Original language	English (US)
Pages (from-to)	244-246
Number of pages	3
Journal	Cell
Volume	151
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2012.09.031
State	Published - Oct 12 2012
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2012.09.031

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title = "A helicase with an extra spring in its step",

abstract = "DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.",

author = "Michael Schlierf and Taekjip Ha",

note = "Funding Information: This work was supported by grants from BMBF 03Z2EN11 (to M.S.) and U.S. National Institutes of Health GM065367 (to T.H.).",

year = "2012",

month = oct,

day = "12",

doi = "10.1016/j.cell.2012.09.031",

language = "English (US)",

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T1 - A helicase with an extra spring in its step

AU - Schlierf, Michael

AU - Ha, Taekjip

N1 - Funding Information: This work was supported by grants from BMBF 03Z2EN11 (to M.S.) and U.S. National Institutes of Health GM065367 (to T.H.).

PY - 2012/10/12

Y1 - 2012/10/12

N2 - DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.

AB - DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.

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DO - 10.1016/j.cell.2012.09.031

M3 - Short survey

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VL - 151

SP - 244

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JO - Cell

JF - Cell

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ER -

A helicase with an extra spring in its step

Abstract

ASJC Scopus subject areas

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