A Handheld Real-Time Photoacoustic Imaging System for Animal Neurological Disease Models: From Simulation to Realization

Yu Hang Liu, Yu Xu, Lun De Liao, Kim Chuan Chan, Nitish V Thakor

Research output: Contribution to journalArticle

Abstract

This article provides a guide to design and build a handheld, real-time photoacoustic (PA) imaging system from simulation to realization for animal neurological disease models. A pulsed laser and array-based ultrasound (US) platform were utilized to develop the system for evaluating vascular functions in rats with focal ischemia or subcutaneous tumors. To optimize the laser light delivery, finite element (FE)-based simulation models were developed to provide information regarding light propagation and PA wave generation in soft tissues. Besides, simulations were also conducted to evaluate the ideal imaging resolution of the US system. As a result, a PA C-scan image of a designed phantom in 1% Lipofundin was reconstructed with depth information. Performance of the handheld PA system was tested in an animal ischemia model, which revealed that cerebral blood volume (CBV) changes at the cortical surface could be monitored immediately after ischemia induction. Another experiment on subcutaneous tumors showed the anomalous distribution of the total hemoglobin concentration (HbT) and oxygen saturation (SO₂), while 3D and maximum intensity projection (MIP) PA images of the subcutaneous tumors are also presented in this article. Overall, this system shows promise for monitoring disease progression in vascular functional impairments.

Original languageEnglish (US)
JournalSensors (Basel, Switzerland)
Volume18
Issue number11
DOIs
StatePublished - Nov 21 2018

Fingerprint

Neurological Models
Animal Disease Models
ischemia
Photoacoustic effect
Imaging systems
animals
Animals
tumors
Ischemia
Blood Vessels
Lasers
Tumors
blood volume
Light
Neoplasms
simulation
wave generation
impairment
hemoglobin
progressions

Keywords

  • neurological disease
  • photoacoustic imaging
  • stroke
  • tumor
  • vascular function

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Biochemistry
  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

A Handheld Real-Time Photoacoustic Imaging System for Animal Neurological Disease Models : From Simulation to Realization. / Liu, Yu Hang; Xu, Yu; Liao, Lun De; Chan, Kim Chuan; Thakor, Nitish V.

In: Sensors (Basel, Switzerland), Vol. 18, No. 11, 21.11.2018.

Research output: Contribution to journalArticle

@article{0db68c0fab3e4e9c8d7ddd0146479b11,
title = "A Handheld Real-Time Photoacoustic Imaging System for Animal Neurological Disease Models: From Simulation to Realization",
abstract = "This article provides a guide to design and build a handheld, real-time photoacoustic (PA) imaging system from simulation to realization for animal neurological disease models. A pulsed laser and array-based ultrasound (US) platform were utilized to develop the system for evaluating vascular functions in rats with focal ischemia or subcutaneous tumors. To optimize the laser light delivery, finite element (FE)-based simulation models were developed to provide information regarding light propagation and PA wave generation in soft tissues. Besides, simulations were also conducted to evaluate the ideal imaging resolution of the US system. As a result, a PA C-scan image of a designed phantom in 1{\%} Lipofundin was reconstructed with depth information. Performance of the handheld PA system was tested in an animal ischemia model, which revealed that cerebral blood volume (CBV) changes at the cortical surface could be monitored immediately after ischemia induction. Another experiment on subcutaneous tumors showed the anomalous distribution of the total hemoglobin concentration (HbT) and oxygen saturation (SO₂), while 3D and maximum intensity projection (MIP) PA images of the subcutaneous tumors are also presented in this article. Overall, this system shows promise for monitoring disease progression in vascular functional impairments.",
keywords = "neurological disease, photoacoustic imaging, stroke, tumor, vascular function",
author = "Liu, {Yu Hang} and Yu Xu and Liao, {Lun De} and Chan, {Kim Chuan} and Thakor, {Nitish V}",
year = "2018",
month = "11",
day = "21",
doi = "10.3390/s18114081",
language = "English (US)",
volume = "18",
journal = "Sensors",
issn = "1424-3210",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",

}

TY - JOUR

T1 - A Handheld Real-Time Photoacoustic Imaging System for Animal Neurological Disease Models

T2 - From Simulation to Realization

AU - Liu, Yu Hang

AU - Xu, Yu

AU - Liao, Lun De

AU - Chan, Kim Chuan

AU - Thakor, Nitish V

PY - 2018/11/21

Y1 - 2018/11/21

N2 - This article provides a guide to design and build a handheld, real-time photoacoustic (PA) imaging system from simulation to realization for animal neurological disease models. A pulsed laser and array-based ultrasound (US) platform were utilized to develop the system for evaluating vascular functions in rats with focal ischemia or subcutaneous tumors. To optimize the laser light delivery, finite element (FE)-based simulation models were developed to provide information regarding light propagation and PA wave generation in soft tissues. Besides, simulations were also conducted to evaluate the ideal imaging resolution of the US system. As a result, a PA C-scan image of a designed phantom in 1% Lipofundin was reconstructed with depth information. Performance of the handheld PA system was tested in an animal ischemia model, which revealed that cerebral blood volume (CBV) changes at the cortical surface could be monitored immediately after ischemia induction. Another experiment on subcutaneous tumors showed the anomalous distribution of the total hemoglobin concentration (HbT) and oxygen saturation (SO₂), while 3D and maximum intensity projection (MIP) PA images of the subcutaneous tumors are also presented in this article. Overall, this system shows promise for monitoring disease progression in vascular functional impairments.

AB - This article provides a guide to design and build a handheld, real-time photoacoustic (PA) imaging system from simulation to realization for animal neurological disease models. A pulsed laser and array-based ultrasound (US) platform were utilized to develop the system for evaluating vascular functions in rats with focal ischemia or subcutaneous tumors. To optimize the laser light delivery, finite element (FE)-based simulation models were developed to provide information regarding light propagation and PA wave generation in soft tissues. Besides, simulations were also conducted to evaluate the ideal imaging resolution of the US system. As a result, a PA C-scan image of a designed phantom in 1% Lipofundin was reconstructed with depth information. Performance of the handheld PA system was tested in an animal ischemia model, which revealed that cerebral blood volume (CBV) changes at the cortical surface could be monitored immediately after ischemia induction. Another experiment on subcutaneous tumors showed the anomalous distribution of the total hemoglobin concentration (HbT) and oxygen saturation (SO₂), while 3D and maximum intensity projection (MIP) PA images of the subcutaneous tumors are also presented in this article. Overall, this system shows promise for monitoring disease progression in vascular functional impairments.

KW - neurological disease

KW - photoacoustic imaging

KW - stroke

KW - tumor

KW - vascular function

UR - http://www.scopus.com/inward/record.url?scp=85057114468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057114468&partnerID=8YFLogxK

U2 - 10.3390/s18114081

DO - 10.3390/s18114081

M3 - Article

C2 - 30469455

AN - SCOPUS:85057114468

VL - 18

JO - Sensors

JF - Sensors

SN - 1424-3210

IS - 11

ER -