A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus

Gilles de Hollander, Max C. Keuken, Pierre Louis Bazin, Marcel Weiss, Jane Neumann, Katja Reimann, Miriam Wähnert, Robert Turner, Birte U. Forstmann, Andreas Schäfer

Research output: Contribution to journalArticle

Abstract

The subthalamic nucleus (STN) is an important node of the cortico-basal ganglia network and the main target of deep brain stimulation (DBS) in Parkinson's disease. Histological studies have revealed an inhomogeneous iron distribution within the STN, which has been related to putative subdivisions within this nucleus. Here, we investigate the iron distribution in more detail using quantitative susceptibility mapping (QSM), a novel magnetic resonance imaging (MRI) contrast mechanism. QSM allows for detailed assessment of iron content in both in vivo and postmortem tissue. Twelve human participants and 7 postmortem brain samples containing the STN were scanned using ultra-high field 7 Tesla (T) MRI. Iron concentrations were found to be higher in the medial-inferior tip of the STN. Using quantitative methods we show that the increase of iron concentration towards the medial-inferior tip is of a gradual rather than a discrete nature.

Original languageEnglish (US)
Pages (from-to)4440-4449
Number of pages10
JournalHuman Brain Mapping
Volume35
Issue number9
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Subthalamic Nucleus
Iron
Magnetic Resonance Imaging
Deep Brain Stimulation
Basal Ganglia
Parkinson Disease
Brain

Keywords

  • 7T MRI
  • Iron gradients
  • Quantitative susceptibility mapping
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

Cite this

de Hollander, G., Keuken, M. C., Bazin, P. L., Weiss, M., Neumann, J., Reimann, K., ... Schäfer, A. (2014). A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus. Human Brain Mapping, 35(9), 4440-4449. https://doi.org/10.1002/hbm.22485

A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus. / de Hollander, Gilles; Keuken, Max C.; Bazin, Pierre Louis; Weiss, Marcel; Neumann, Jane; Reimann, Katja; Wähnert, Miriam; Turner, Robert; Forstmann, Birte U.; Schäfer, Andreas.

In: Human Brain Mapping, Vol. 35, No. 9, 2014, p. 4440-4449.

Research output: Contribution to journalArticle

de Hollander, G, Keuken, MC, Bazin, PL, Weiss, M, Neumann, J, Reimann, K, Wähnert, M, Turner, R, Forstmann, BU & Schäfer, A 2014, 'A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus', Human Brain Mapping, vol. 35, no. 9, pp. 4440-4449. https://doi.org/10.1002/hbm.22485
de Hollander G, Keuken MC, Bazin PL, Weiss M, Neumann J, Reimann K et al. A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus. Human Brain Mapping. 2014;35(9):4440-4449. https://doi.org/10.1002/hbm.22485
de Hollander, Gilles ; Keuken, Max C. ; Bazin, Pierre Louis ; Weiss, Marcel ; Neumann, Jane ; Reimann, Katja ; Wähnert, Miriam ; Turner, Robert ; Forstmann, Birte U. ; Schäfer, Andreas. / A gradual increase of iron toward the medial-inferior tip of the subthalamic nucleus. In: Human Brain Mapping. 2014 ; Vol. 35, No. 9. pp. 4440-4449.
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