A goblet cell-rich variant of conjunctival mucoepidermoid carcinoma

B. D. Simons, M. E. Sulewski, W. C. Frayer, A. B. Leahey, R. L. Font, S. E. Orlin, E. Lilley

Research output: Contribution to journalArticlepeer-review


Purpose. To present the history, histopathology, and management of a case of recurrent adenocarcinoma of the conjunctiva and cornea. Methods. A 77 year old African American male presented with hand motions acuity and a large keratoconjunctival mass OS. He underwent an excisional biopsy with recurrence of the tumor two years later. Results. Histopathology revealed a configuration most consistent with a malignant tumor as well as an unusually large predominance of goblet cells and minimal epidermoid cells. The visual acuity improved to 20/30 OS with no evidence of local recurrence of the tumor at one year. At two years follow-up, the visual acuity was 20/60 and there was recurrence of a keratoconjunctival mass. The patient underwent repeat excision with cryotherapy of the surrounding conjunctival edges. The recurrent tumor displayed a similar goblet cell-rich variant of the conjunctival mucoepidermoid carcinoma. Conclusions. Incomplete excision without adequate cryotherpay may predispose to recurrence of this carcinoma. Systemic evaluation, complete excision with cryotherapy, and close observation is the recommended management of this rare conjunctival tumor.

Original languageEnglish (US)
Pages (from-to)S245
JournalInvestigative Ophthalmology and Visual Science
Issue number3
StatePublished - Feb 15 1996
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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