TY - JOUR
T1 - A global assessment of eye health and quality of life a systematic review of systematic reviews
AU - Assi, Lama
AU - Chamseddine, Fatimah
AU - Ibrahim, Perla
AU - Sabbagh, Hadi
AU - Rosman, Lori
AU - Congdon, Nathan
AU - Evans, Jennifer
AU - Ramke, Jacqueline
AU - Kuper, Hannah
AU - Burton, Matthew J.
AU - Ehrlich, Joshua R.
AU - Swenor, Bonnielin K.
N1 - Funding Information:
Funding/Support: Dr Swenor is supported by a
Funding Information:
reports being the director of research at Orbis International, a nongovernmental organization working to promote eye health in low-and middle-income countries, and receiving personal fees from Belkin Laser outside the submitted work. Dr Ehrlich reports a grant from National Institutes of Health (grant K23EY027848) during the conduct of the study. Dr Swenor reports grants from National Institute on Aging during the conduct of the study. Dr Rosman reports grants from National Eye Institute (grant UG1-EY020522-08) outside the submitted work. Dr Ramke reports funding from the Commonwealth Scholarship Commission (as a Commonwealth Rutherford Fellow) via the UK government and grants from Moorfields Eye Charity (grant GR001061) during the conduct of the study, as well as financial support from the Buchanan Charitable Foundation, New Zealand, outside the submitted work. No other disclosures were reported.
Publisher Copyright:
© 2021 American Medical Association.
PY - 2021/5
Y1 - 2021/5
N2 - IMPORTANCE More than 1 billion people worldwide have vision impairment or blindness from potentially preventable or correctable causes. Quality of life, an important measure of physical, emotional, and social well-being, appears to be negatively associated with vision impairment, and increasingly, ophthalmic interventions are being assessed for their association with quality of life. OBJECTIVE To examine the association between vision impairment or eye disease and quality of life, and the outcome of ophthalmic interventions on quality of life globally and across the life span, through an umbrella review or systematic review of systematic reviews. EVIDENCE REVIEW The electronic databases MEDLINE, Ovid, Embase, Cochrane Database of Systematic Reviews, Proquest Dissertations, and Theses Global were searched from inception through June 29, 2020, using a comprehensive search strategy. Systematic reviews addressing vision impairment, eye disease, or ophthalmic interventions and quantitatively or qualitatively assessing health-related, vision-related, or disease-specific quality of life were included. Article screening, quality appraisal, and data extraction were performed by 4 reviewers working independently and in duplicate. The Joanna Briggs Institute critical appraisal and data extraction forms for umbrella reviews were used. FINDINGS Nine systematic reviews evaluated the association between quality of life and vision impairment, age-related macular degeneration, glaucoma, diabetic retinopathy, or mendelian eye conditions (including retinitis pigmentosa). Of these, 5 were reviews of quantitative observational studies, 3 were reviews of qualitative studies, and 1 was a review of qualitative and quantitative studies. All found an association between vision impairment and lower quality of life. Sixty systematic reviews addressed at least 1 ophthalmic intervention in association with quality of life. Overall, 33 unique interventions were investigated, of which 25 were found to improve quality of life compared with baseline measurements or a group receiving no intervention. These interventions included timely cataract surgery, anti-vascular endothelial growth factor therapy for age-related macular degeneration, and macular edema. CONCLUSIONS AND RELEVANCE There is a consistent association between vision impairment, eye diseases, and reduced quality of life. These findings support pursuing ophthalmic interventions, such as timely cataract surgery and anti-vascular endothelial growth factor therapy, for common retinal diseases, where indicated, to improve quality of life for millions of people globally each year.
AB - IMPORTANCE More than 1 billion people worldwide have vision impairment or blindness from potentially preventable or correctable causes. Quality of life, an important measure of physical, emotional, and social well-being, appears to be negatively associated with vision impairment, and increasingly, ophthalmic interventions are being assessed for their association with quality of life. OBJECTIVE To examine the association between vision impairment or eye disease and quality of life, and the outcome of ophthalmic interventions on quality of life globally and across the life span, through an umbrella review or systematic review of systematic reviews. EVIDENCE REVIEW The electronic databases MEDLINE, Ovid, Embase, Cochrane Database of Systematic Reviews, Proquest Dissertations, and Theses Global were searched from inception through June 29, 2020, using a comprehensive search strategy. Systematic reviews addressing vision impairment, eye disease, or ophthalmic interventions and quantitatively or qualitatively assessing health-related, vision-related, or disease-specific quality of life were included. Article screening, quality appraisal, and data extraction were performed by 4 reviewers working independently and in duplicate. The Joanna Briggs Institute critical appraisal and data extraction forms for umbrella reviews were used. FINDINGS Nine systematic reviews evaluated the association between quality of life and vision impairment, age-related macular degeneration, glaucoma, diabetic retinopathy, or mendelian eye conditions (including retinitis pigmentosa). Of these, 5 were reviews of quantitative observational studies, 3 were reviews of qualitative studies, and 1 was a review of qualitative and quantitative studies. All found an association between vision impairment and lower quality of life. Sixty systematic reviews addressed at least 1 ophthalmic intervention in association with quality of life. Overall, 33 unique interventions were investigated, of which 25 were found to improve quality of life compared with baseline measurements or a group receiving no intervention. These interventions included timely cataract surgery, anti-vascular endothelial growth factor therapy for age-related macular degeneration, and macular edema. CONCLUSIONS AND RELEVANCE There is a consistent association between vision impairment, eye diseases, and reduced quality of life. These findings support pursuing ophthalmic interventions, such as timely cataract surgery and anti-vascular endothelial growth factor therapy, for common retinal diseases, where indicated, to improve quality of life for millions of people globally each year.
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U2 - 10.1001/jamaophthalmol.2021.0146
DO - 10.1001/jamaophthalmol.2021.0146
M3 - Review article
C2 - 33576772
AN - SCOPUS:85100819039
SN - 2168-6165
VL - 139
SP - 526
EP - 541
JO - JAMA ophthalmology
JF - JAMA ophthalmology
IS - 5
ER -