A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans

Bonnie A. Thiel, Aravinda Chakravarti, Richard S. Cooper, Amy Luke, Sue Lewis, Audrey Lynn, Hemant Tiwari, Nicholas J. Schork, Alan B. Weder

Research output: Contribution to journalArticle

Abstract

Evidence for genomic regions influencing systolic and diastolic blood pressure (BP) were assessed in a whole genome linkage analysis in 211 African American and 160 white families as part of the GenNet network of the National Heart, Lung and Blood Institute-sponsored Family Blood Pressure Program. Multipoint regression and variance components linkage methods were used to analyze 372 polymorphic markers. Statistically compelling evidence for linkage (P values .0057 and .00023, respectively) was found on chromosome 1. Our results support the idea that BP regulation is most likely governed by multiple genetic loci, each with a relatively weak effect on BP in the population at large.

Original languageEnglish (US)
Pages (from-to)151-153
Number of pages3
JournalAmerican Journal of Hypertension
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2003

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Keywords

  • Blood pressure
  • Genetics
  • Heredity
  • Hypertension
  • Linkage analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Thiel, B. A., Chakravarti, A., Cooper, R. S., Luke, A., Lewis, S., Lynn, A., Tiwari, H., Schork, N. J., & Weder, A. B. (2003). A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans. American Journal of Hypertension, 16(2), 151-153. https://doi.org/10.1016/S0895-7061(02)03246-6