@article{d7cff9cf2c894e7f8834be8ce2a96865,
title = "A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3",
abstract = "Genome-wide and candidate-gene association studies of bladder cancer have identified 10 susceptibility loci thus far. We conducted a meta-analysis of two previously published genome-wide scans (4501 cases and 6076 controls of European background) and followed up the most significant association signals [17 single nucleotide polymorphisms (SNPs) in 10 genomic regions] in 1382 cases and 2201 controls from four studies. A combined analysis adjusted for study center, age, sex, and smoking status identified a novel susceptibility locus that mapped to a region of 18q12.3, marked by rs7238033 (P = 8.7 × 10 -9; allelic odds ratio 1.20 with 95% CI: 1.13-1.28) and two highly correlated SNPs, rs10775480/rs10853535 (r 2= 1.00; P = 8.9 × 10 -9; allelic odds ratio 1.16 with 95% CI: 1.10-1.22). The signal localizes to the solute carrier family 14 member 1 gene, SLC14A1, a urea transporter that regulates cellular osmotic pressure. In the kidney, SLC14A1 regulates urine volume and concentration whereas in erythrocytes it determines the Kidd blood groups. Our findings suggest that genetic variation in SLC14A1 could provide new etiological insights into bladder carcinogenesis. Published by Oxford University Press 2011.",
author = "Montserrat Garcia-closas and Yuanqing Ye and Nathaniel Rothman and Figueroa, {Jonine D.} and N{\'u}ria Malats and Dinney, {Colin P.} and Nilanjan Chatterjee and Ludmila Prokunina-olsson and Zhaoming Wang and Jie Lin and Real, {Francisco X.} and Jacobs, {Kevin B.} and Dalsu Baris and Michael Thun and {De vivo}, Immaculata and Demetrius Albanes and Purdue, {Mark P.} and Manolis Kogevinas and Kamat, {Ashish M.} and Lerner, {Seth P.} and {Barton grossman}, H. and Jian Gu and Xia Pu and Amy Hutchinson and Fu, {Yi Ping} and Laurie Burdett and Meredith Yeager and Wei Tang and Adonina Tard{\'o}n and Consol Serra and Alfredo Carrato and Reina Garc{\'i}a-closas and Josep Lloreta and Alison Johnson and Molly Schwenn and Karagas, {Margaret R.} and Alan Schned and Gerald Andriole and Robert Grubb and Amanda Black and Jacobs, {Eric J.} and {Ryan diver}, W. and Gapstur, {Susan M.} and Weinstein, {Stephanie J.} and Jarmo Virtamo and Hunter, {David J.} and Neil Caporaso and {Teresa landi}, Maria and Fraumeni, {Joseph F.} and Silverman, {Debra T.} and Chanock, {Stephen J.} and Xifeng Wu",
note = "Funding Information: SBCS (D.T.S., N.R., S.J.C., M.G.C.)—Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics and intramural contract number NCI N02-CP-11015. FIS/Spain 98/1274, FIS/Spain 00/0745, PI061614 and G03/174, Funda-ci{\'o} Marat{\'o} TV3, Red Tem{\'a}tica Investigaci{\'o}n Cooperativa en C{\'a}ncer (RTICC), Consol{\'i}der ONCOBIO, EU-FP7-201663; and RO1-CA089715 and CA34627. Funding Information: The NCI bladder cancer GWAS was supported by the intramural research program of the National Institutes of Health, National Cancer Institute. This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Funding Information: PLCO (M.P.P)—the NIH Genes, Environment and Health Initiative (GEI) partly funded DNA extraction and statistical analyses (HG-06-033-NCI-01 and RO1HL091172-01), geno-typing at the Johns Hopkins University Center for Inherited Disease Research (U01HG004438 and NIH HHSN26820 0782096C) and study coordination at the GENEVA (N.C.)— The NIH Genes, Environment and Health Initiative (GEI) partly funded DNA extraction and statistical analyses (HG-06-033-NCI-01 and RO1HL091172-01), genotyping at the Johns Hopkins University Center for Inherited Disease Research (U01HG004438 and NIH HHSN268200782096C) and study coordination at the GENEVA Coordination Center (U01 HG004446) for EAGLE and part of PLCO studies. Genotyping for the remaining part of PLCO and all ATBC and CPS-II samples were supported by the Intramural Research Program of the National Institutes of Health, NCI, Division of Cancer Epidemiology and Genetics. The PLCO is supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics and supported by contracts from the Division of Cancer Prevention, National Cancer Institute, National Institutes of Health. Funding Information: ATBC (D.A.)—this research was supported in part by the Intramural Research Program of the NIH and the National Cancer Institute. Additionally, this research was supported by U.S. Public Health Service contracts N01-CN-45165, N01-RC-45035 and N01-RC-37004 from the National Cancer Institute, Department of Health and Human Services. Funding Information: NEBCS (D.T.S.)—Intramural research program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics and intramural contract number NCI N02-CP-01037.",
year = "2011",
month = nov,
doi = "10.1093/hmg/ddr342",
language = "English (US)",
volume = "20",
pages = "4282--4289",
journal = "Human molecular genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "21",
}