TY - JOUR
T1 - A genetic linkage map of 17 markers on human chromosome 21
AU - Warren, Andrew C.
AU - Slaugenhaupt, Susan A.
AU - Lewis, John G.
AU - Chakravarti, Aravinda
AU - Antonarakis, Stylianos E.
N1 - Funding Information:
This research was supported by NIH Grants HD19591 (to S.E.A.) and GM33771 (to A.C.). A.C. was also supported by RCDA HDO0774. A.C.W. was supported by a fellowship from the John Douglas French Foundation. We are grateful to Drs. M. Lathrop, J.-M. Lalouel, E. Lander, and K. Buetow for computer programs and discussion. Computational time from the NIH Shared Computer Facility, Department of Biostatistics, University of Pittsburgh, is gratefully acknowledged. We thank Drs. H. Donis-Keller and P. Green of Collaborative Research, Inc., for providing the genotypic data for five loci on chromosome 21 (Donis-Keller et al., 1987) for reanalysis and inclusion in the map. We also thank Drs. J. Gusella, P. Watkins, Y. Groner, M. L. Chu, G. Scherer, D. Kurnit, K. Davies, T. Papas, and N. Robakis for providing recombinant clones. We thank E. Pasterfield for expert secretarial assistance and J. Strayer for the figures.
PY - 1989/5
Y1 - 1989/5
N2 - We have constructed a genetic linkage map of 17 markers on the long arm of human chromosome 21, including six genes and two anonymous loci with a variable number of tandem repeats. The estimated length of the map is 103 cM in males and 140 cM in females, assuming Kosambi interference. Recombination in females was approximately twice that in males between proximal markers. However, over half of the recombination events in either sex occur distally, in 21q22.3, although this region accounts for only about 15% of the physical length of chromosome 21.
AB - We have constructed a genetic linkage map of 17 markers on the long arm of human chromosome 21, including six genes and two anonymous loci with a variable number of tandem repeats. The estimated length of the map is 103 cM in males and 140 cM in females, assuming Kosambi interference. Recombination in females was approximately twice that in males between proximal markers. However, over half of the recombination events in either sex occur distally, in 21q22.3, although this region accounts for only about 15% of the physical length of chromosome 21.
UR - http://www.scopus.com/inward/record.url?scp=0024673118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024673118&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(89)90282-6
DO - 10.1016/0888-7543(89)90282-6
M3 - Article
C2 - 2568330
AN - SCOPUS:0024673118
SN - 0888-7543
VL - 4
SP - 579
EP - 591
JO - Genomics
JF - Genomics
IS - 4
ER -