A genetic linkage map of 17 markers on human chromosome 21

Andrew C. Warren, Susan A. Slaugenhaupt, John G. Lewis, Aravinda Chakravarti, Stylianos E. Antonarakis

Research output: Contribution to journalArticle

Abstract

We have constructed a genetic linkage map of 17 markers on the long arm of human chromosome 21, including six genes and two anonymous loci with a variable number of tandem repeats. The estimated length of the map is 103 cM in males and 140 cM in females, assuming Kosambi interference. Recombination in females was approximately twice that in males between proximal markers. However, over half of the recombination events in either sex occur distally, in 21q22.3, although this region accounts for only about 15% of the physical length of chromosome 21.

Original languageEnglish (US)
Pages (from-to)579-591
Number of pages13
JournalGenomics
Volume4
Issue number4
DOIs
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Genetics

Cite this

Warren, A. C., Slaugenhaupt, S. A., Lewis, J. G., Chakravarti, A., & Antonarakis, S. E. (1989). A genetic linkage map of 17 markers on human chromosome 21. Genomics, 4(4), 579-591. https://doi.org/10.1016/0888-7543(89)90282-6