A generalized linear integrate-and-fire neural model produces diverse spiking behaviors

Ştefan Mihalaş, Ernst Niebur

Research output: Contribution to journalLetter

Abstract

For simulations of neural networks, there is a trade-off between the size of the network that can be simulated and the complexity of the model used for individual neurons. In this study, we describe a generalization of the leaky integrate-and-fire model that produces a wide variety of spiking behaviors while still being analytically solvable between firings. For different parameter values, the model produces spiking or bursting, tonic, phasic or adapting responses, depolarizing or hyperpolarizing after potentials and so forth. The model consists of a diagonalizable set of linear differential equations describing the time evolution of membrane potential, a variable threshold, and an arbitrary number of firing-induced currents. Each of these variables is modified by an update rule when the potential reaches threshold. The variables used are intuitive and have biological significance. The model's rich behavior does not come from the differential equations, which are linear, but rather from complex update rules. This single-neuron model can be implemented using algorithms similar to the standard integrate-and-fire model. It is a natural match with event-driven algorithms for which the firing times are obtained as a solution of a polynomial equation.

Original languageEnglish (US)
Pages (from-to)704-718
Number of pages15
JournalNeural Computation
Volume21
Issue number3
DOIs
StatePublished - Mar 1 2009

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'A generalized linear integrate-and-fire neural model produces diverse spiking behaviors'. Together they form a unique fingerprint.

  • Cite this