A general framework for achieving integral control in chemotactic biological signaling mechanisms

Pablo A. Iglesias, Andre Levchenko

Research output: Contribution to journalConference articlepeer-review

Abstract

The ability to sense gradients is important for proper functioning of single cell organisms and multi-cellular systems. Most known chemotactic systems are capable of perfect adaptation to spatially uniform changes in the chemoattractant concentration. In control-theoretic terms, this amounts to a step disturbance rejection problem. Thus, cells must be able to implement integral control mechanisms for rejecting these steps. In this paper we describe two general frameworks for achieving integral control in signal transduction pathways.

Original languageEnglish (US)
Pages (from-to)843-848
Number of pages6
JournalProceedings of the IEEE Conference on Decision and Control
Volume1
StatePublished - Dec 1 2001
Event40th IEEE Conference on Decision and Control (CDC) - Orlando, FL, United States
Duration: Dec 4 2001Dec 4 2001

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Modeling and Simulation
  • Control and Optimization

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