A Functional Magnetic Resonance Imaging Investigation of Uncertainty in Adolescents with Anxiety Disorders

Amy L. Krain, Kristin Gotimer, Sara Hefton, Monique Ernst, F. Xavier Castellanos, Daniel S. Pine, Michael P. Milham

Research output: Contribution to journalArticle

Abstract

Background: Pediatric anxiety disorders, although highly prevalent, are understudied with little known about their pathophysiology. Intolerance of uncertainty (IU) is a trait associated with worry, a key characteristic of these disorders. Neural responses to uncertainty in healthy subjects involve the same frontal-limbic circuits that are hyper-responsive in pediatric anxiety. As such, the present study examines the relationship between IU and neural responses to uncertainty in anxious adolescents. Methods: Sixteen adolescents (ages 13-17) diagnosed with generalized anxiety disorder and/or social phobia (ANX) and 13 non-anxious control subjects completed a decision-making task while functional magnetic resonance imaging scans were acquired. Results: The ANX group endorsed greater task-related anxiety and less certainty than control subjects on a post-task questionnaire. Compared with control subjects, the ANX group did not demonstrate hyper-responsivity of brain regions as hypothesized. Across groups, IU was positively correlated with activity in several frontal and limbic regions. Further analyses identified subgroups within the ANX group: those with high IU activated frontal/limbic regions, whereas those with low IU and less anxiety during the task deactivated the same regions in response to uncertainty. Conclusions: Results substantiate the hypothesized link between IU and neural responses to uncertainty in some adolescents with anxiety disorders. Our findings, if replicated, suggest that trait measures, such as IU, can significantly improve our understanding of the neurobiological basis of pediatric anxiety disorders.

Original languageEnglish (US)
Pages (from-to)563-568
Number of pages6
JournalBiological Psychiatry
Volume63
Issue number6
DOIs
StatePublished - Mar 15 2008
Externally publishedYes

Fingerprint

Anxiety Disorders
Uncertainty
Magnetic Resonance Imaging
Anxiety
Pediatrics
Decision Making
Healthy Volunteers

Keywords

  • Adolescence
  • anxiety
  • decision-making
  • fMRI
  • uncertainty

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Krain, A. L., Gotimer, K., Hefton, S., Ernst, M., Castellanos, F. X., Pine, D. S., & Milham, M. P. (2008). A Functional Magnetic Resonance Imaging Investigation of Uncertainty in Adolescents with Anxiety Disorders. Biological Psychiatry, 63(6), 563-568. https://doi.org/10.1016/j.biopsych.2007.06.011

A Functional Magnetic Resonance Imaging Investigation of Uncertainty in Adolescents with Anxiety Disorders. / Krain, Amy L.; Gotimer, Kristin; Hefton, Sara; Ernst, Monique; Castellanos, F. Xavier; Pine, Daniel S.; Milham, Michael P.

In: Biological Psychiatry, Vol. 63, No. 6, 15.03.2008, p. 563-568.

Research output: Contribution to journalArticle

Krain, AL, Gotimer, K, Hefton, S, Ernst, M, Castellanos, FX, Pine, DS & Milham, MP 2008, 'A Functional Magnetic Resonance Imaging Investigation of Uncertainty in Adolescents with Anxiety Disorders', Biological Psychiatry, vol. 63, no. 6, pp. 563-568. https://doi.org/10.1016/j.biopsych.2007.06.011
Krain, Amy L. ; Gotimer, Kristin ; Hefton, Sara ; Ernst, Monique ; Castellanos, F. Xavier ; Pine, Daniel S. ; Milham, Michael P. / A Functional Magnetic Resonance Imaging Investigation of Uncertainty in Adolescents with Anxiety Disorders. In: Biological Psychiatry. 2008 ; Vol. 63, No. 6. pp. 563-568.
@article{248177baaf3b473ab956fe459ebf19ef,
title = "A Functional Magnetic Resonance Imaging Investigation of Uncertainty in Adolescents with Anxiety Disorders",
abstract = "Background: Pediatric anxiety disorders, although highly prevalent, are understudied with little known about their pathophysiology. Intolerance of uncertainty (IU) is a trait associated with worry, a key characteristic of these disorders. Neural responses to uncertainty in healthy subjects involve the same frontal-limbic circuits that are hyper-responsive in pediatric anxiety. As such, the present study examines the relationship between IU and neural responses to uncertainty in anxious adolescents. Methods: Sixteen adolescents (ages 13-17) diagnosed with generalized anxiety disorder and/or social phobia (ANX) and 13 non-anxious control subjects completed a decision-making task while functional magnetic resonance imaging scans were acquired. Results: The ANX group endorsed greater task-related anxiety and less certainty than control subjects on a post-task questionnaire. Compared with control subjects, the ANX group did not demonstrate hyper-responsivity of brain regions as hypothesized. Across groups, IU was positively correlated with activity in several frontal and limbic regions. Further analyses identified subgroups within the ANX group: those with high IU activated frontal/limbic regions, whereas those with low IU and less anxiety during the task deactivated the same regions in response to uncertainty. Conclusions: Results substantiate the hypothesized link between IU and neural responses to uncertainty in some adolescents with anxiety disorders. Our findings, if replicated, suggest that trait measures, such as IU, can significantly improve our understanding of the neurobiological basis of pediatric anxiety disorders.",
keywords = "Adolescence, anxiety, decision-making, fMRI, uncertainty",
author = "Krain, {Amy L.} and Kristin Gotimer and Sara Hefton and Monique Ernst and Castellanos, {F. Xavier} and Pine, {Daniel S.} and Milham, {Michael P.}",
year = "2008",
month = "3",
day = "15",
doi = "10.1016/j.biopsych.2007.06.011",
language = "English (US)",
volume = "63",
pages = "563--568",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - A Functional Magnetic Resonance Imaging Investigation of Uncertainty in Adolescents with Anxiety Disorders

AU - Krain, Amy L.

AU - Gotimer, Kristin

AU - Hefton, Sara

AU - Ernst, Monique

AU - Castellanos, F. Xavier

AU - Pine, Daniel S.

AU - Milham, Michael P.

PY - 2008/3/15

Y1 - 2008/3/15

N2 - Background: Pediatric anxiety disorders, although highly prevalent, are understudied with little known about their pathophysiology. Intolerance of uncertainty (IU) is a trait associated with worry, a key characteristic of these disorders. Neural responses to uncertainty in healthy subjects involve the same frontal-limbic circuits that are hyper-responsive in pediatric anxiety. As such, the present study examines the relationship between IU and neural responses to uncertainty in anxious adolescents. Methods: Sixteen adolescents (ages 13-17) diagnosed with generalized anxiety disorder and/or social phobia (ANX) and 13 non-anxious control subjects completed a decision-making task while functional magnetic resonance imaging scans were acquired. Results: The ANX group endorsed greater task-related anxiety and less certainty than control subjects on a post-task questionnaire. Compared with control subjects, the ANX group did not demonstrate hyper-responsivity of brain regions as hypothesized. Across groups, IU was positively correlated with activity in several frontal and limbic regions. Further analyses identified subgroups within the ANX group: those with high IU activated frontal/limbic regions, whereas those with low IU and less anxiety during the task deactivated the same regions in response to uncertainty. Conclusions: Results substantiate the hypothesized link between IU and neural responses to uncertainty in some adolescents with anxiety disorders. Our findings, if replicated, suggest that trait measures, such as IU, can significantly improve our understanding of the neurobiological basis of pediatric anxiety disorders.

AB - Background: Pediatric anxiety disorders, although highly prevalent, are understudied with little known about their pathophysiology. Intolerance of uncertainty (IU) is a trait associated with worry, a key characteristic of these disorders. Neural responses to uncertainty in healthy subjects involve the same frontal-limbic circuits that are hyper-responsive in pediatric anxiety. As such, the present study examines the relationship between IU and neural responses to uncertainty in anxious adolescents. Methods: Sixteen adolescents (ages 13-17) diagnosed with generalized anxiety disorder and/or social phobia (ANX) and 13 non-anxious control subjects completed a decision-making task while functional magnetic resonance imaging scans were acquired. Results: The ANX group endorsed greater task-related anxiety and less certainty than control subjects on a post-task questionnaire. Compared with control subjects, the ANX group did not demonstrate hyper-responsivity of brain regions as hypothesized. Across groups, IU was positively correlated with activity in several frontal and limbic regions. Further analyses identified subgroups within the ANX group: those with high IU activated frontal/limbic regions, whereas those with low IU and less anxiety during the task deactivated the same regions in response to uncertainty. Conclusions: Results substantiate the hypothesized link between IU and neural responses to uncertainty in some adolescents with anxiety disorders. Our findings, if replicated, suggest that trait measures, such as IU, can significantly improve our understanding of the neurobiological basis of pediatric anxiety disorders.

KW - Adolescence

KW - anxiety

KW - decision-making

KW - fMRI

KW - uncertainty

UR - http://www.scopus.com/inward/record.url?scp=39449128305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39449128305&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2007.06.011

DO - 10.1016/j.biopsych.2007.06.011

M3 - Article

C2 - 17719566

AN - SCOPUS:39449128305

VL - 63

SP - 563

EP - 568

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 6

ER -