A functional cyclooxygenase enzyme is not required for mediation of the pleiotropic effects of human alpha or beta interferon

Robert L. Forti, William M. Mitchell, Robert J. Workman, James T. Forbes, Walter C. Hubbard

Research output: Contribution to journalArticle

Abstract

Aspirin, indomethacin, and phenbutazone at 50 μM concentration inhibit cyclooxygenase in cultured human foreskin fibroblasts as evidence by the suppression of the major prostaglandin species which aaccumulate in the culture medium. In contrast to data reported for mouse interferon on target mouse cells, these agents have no effect on the introduction of antiviral activity by human α and β interferons. Similarly, these agents have no effect on interferon induced inhibition of cell growth in vitro or on interferon induced natural killer cell activity.

Original languageEnglish (US)
Pages (from-to)409-420
Number of pages12
JournalProstaglandins
Volume26
Issue number3
DOIs
StatePublished - Sep 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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