A functional basis for the association of HLA class II genes adn susceptibility to multiple sclerosis: cellular immune responses to myelin basic protein in a multiplex family

Rhonda R. Voskuhl, Roland Martin, Henry F. McFarland

Research output: Contribution to journalArticlepeer-review

Abstract

This study has examined the cellular response to myelin basic protein (MBP) ina multiplex family with multiple sclerosis (MS). A total of 81 MBP-specific T cell liens (TCLs) were derived from three affected siblings and four healthy siblings. No difference was observed in estimated precursor frequenceis of MBP-specific TCLs or peptide specificity of TCLs when comparing affected and unaffected siblings. MPB-specific TCLs from affected siblings, however, were restricted to the DRw15/DQw6 allele more frequently than those from unaffected siblings (P <0.02). These data suggest that restriction of autoantigen-specific T cells may be the functional basis for disease susceptibility related to HLA class II inheritance.

Original languageEnglish (US)
Pages (from-to)199-207
Number of pages9
JournalJournal of Neuroimmunology
Volume42
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • HLA class II
  • Multiple sclerosis
  • Myelin basic protein

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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