A fully-automated peak extraction and baseline estimation method for high-throughput MALDI-TOF-MS-based detection of biological agents

J. Lin, W. Bryden, Fernando J Pineda, C. Resch, A. Saksena, A. Feldman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

High-throughput MALDI-TOF-MS-based detection of biological agents by using fully-automated peak extraction and baseline estimation method was discussed. For the experiment, MS signal was first deconvolved into a baseline and a set of elemental spectral lines. The baseline was then estimated using a novel non-linear, low-pass filtering algorithm. It was suggested that the technique yields the set of peak centers, signal/noise values, and uncertainities required for peak-matching-based algorithms for agent detection and identification.

Original languageEnglish (US)
Title of host publicationProceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics
Pages709-710
Number of pages2
Publication statusPublished - 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

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ASJC Scopus subject areas

  • Spectroscopy

Cite this

Lin, J., Bryden, W., Pineda, F. J., Resch, C., Saksena, A., & Feldman, A. (2002). A fully-automated peak extraction and baseline estimation method for high-throughput MALDI-TOF-MS-based detection of biological agents. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 709-710)