A framework for the pre-clinical validation of LBM-EP for the planning and guidance of ventricular tachycardia ablation

Tommaso Mansi, Roy Beinart, Oliver Zettinig, Saikiran Rapaka, Bogdan Georgescu, Ali Kamen, Yoav Dori, M. Muz Zviman, Daniel A. Herzka, Henry R. Halperin, Dorin Comaniciu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This manuscript presents a framework for the pre-clinical validation of LBM-EP, a fast cardiac electrophysiology model based on the lattice-Boltzmann method (LBM). The overarching goal is to assess whether the model is able to predict ventricular tachycardia (VT) induction given lead location and stimulation protocol. First, the randomwalk algorithm is used to interactively segment the heart ventricles from delayed-enhancement magnetic resonance images (DE-MRI). Scar and border zone are visually delineated using image thresholding. Then, a detailed anatomical model is generated, comprising fiber architecture and spatial distribution of action potential duration. That information is rasterized to a Cartesian grid, and the cardiac potentials are computed. The framework is illustrated on one swine data, for which two different pacing protocols at four different sites were tested. Each of the protocols were then virtually tested by computing seven seconds of heart beat. Model predictions in terms of VT induction were compared with what was observed in the animal. Our parallel implementation on graphics processing units required a total computation time of about two minutes at an isotropic grid resolution of 0.8 mm (21s at a resolution of 1.5 mm), thus enabling interactive VT testing.

Original languageEnglish (US)
Title of host publicationStatistical Atlases and Computational Models of the Heart
Subtitle of host publicationImaging and Modelling Challenges - 4th International Workshop, STACOM 2013, Held in Conjunction with MICCAI 2013, Revised Selected Papers
PublisherSpringer Verlag
Pages253-261
Number of pages9
ISBN (Print)9783642542671
DOIs
StatePublished - Jan 1 2014
Event4th International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2013, Held in Conjunction with MICCAI 2013 - Nagoya, Japan
Duration: Sep 26 2013Sep 26 2013

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8330 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other4th International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2013, Held in Conjunction with MICCAI 2013
CountryJapan
CityNagoya
Period9/26/139/26/13

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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