A follow-up study of Toxoplasma gondii infection in southern Brazil

Claudio Silveira, Rubens Belfort, Cristina Muccioli, Mariza T. Abreu, Maria C. Martins, Cesar Victora, Robert B. Nussenblatt, Gary N. Holland

Research output: Contribution to journalArticle

Abstract

PURPOSE: To understand better the natural history of ocular toxoplasmosis by reexamining a well-characterized population in Southern Brazil. METHODS: Ophthalmological examination and serologic tests for Toxoplasma gondii infection were performed in 1997 on 383 individuals who had undergone the same evaluation in 1990.RESULTS: Of 109 seronegative subjects in 1990, 21 (19.3%) became seropositive by 1997, and 2 (1.5% of previously seronegative patients; 9.5% of those known to have seroconverted) developed ocular toxoplasmosis. Seroconversion occurred more frequently in individuals under 17 years of age (16 of 46 patients, 34.8%) than in those greater than 17 years of age (5 of 63 patients, 7.9%; p = 0.002). Of 131 seropositive individuals who did not have ocular lesions in 1990, 11 (8.3%) had typical toxoplasmic lesions in 1997. Of the 13 individuals with non-specific hyperpigmented small retinal lesions in 1990, 3 (23%) presented with typical lesions in 1997. CONCLUSIONS: Acquired T. gondii infection can result in late development of ocular lesions. Small, non-specific hyperpigmented retinal lesions may represent sites of T. gondii infection in seropositive individuals.

Original languageEnglish (US)
Pages (from-to)351-354
Number of pages4
JournalAmerican Journal of Ophthalmology
Volume131
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Ophthalmology

Cite this

Silveira, C., Belfort, R., Muccioli, C., Abreu, M. T., Martins, M. C., Victora, C., Nussenblatt, R. B., & Holland, G. N. (2001). A follow-up study of Toxoplasma gondii infection in southern Brazil. American Journal of Ophthalmology, 131(3), 351-354. https://doi.org/10.1016/S0002-9394(00)00830-8