A flow cytometric study of non-small cell lung cancer classified as T1NO

R. A. Schmidt, V. W. Rusch, S. Piantadosi

    Research output: Contribution to journalArticle

    Abstract

    Surgical resection currently offers the best chance for cure of non-small cell lung cancer but its efficacy is limited by subsequent tumor recurrence. Even the most favorable cancers (T1NO tumors) recur 20% to 30% of the time within 5 years and there is currently no way to anticipate precisely which tumors will recur. To test whether DNA flow cytometric study might be useful in this regard, the authors performed a retrospective case-control study of 102 tumors (51 recurrent cases and 51 controls) from a prospective registry of patients with completely resected, meticulously staged T1NO non-small cell carcinomas. Unbiased relative hazard ratios of recurrence were estimated for ploidy and proliferative rate, as well as for tumor histologic type and clinical variables. Ploidy abnormalities were slightly more common among cases (67%) than controls (57%) but this difference was not statistically significant. Estimation of proliferative rates was possible for 85 tumors but there was no significant difference between cases and controls and proliferative rates were not prognostic of recurrence. In multivariate analyses, the observed predictive value for each of the flow cytometric parameters was modest at best and smaller than that seen for tumor histologic type. These results suggest that flow cytometric analysis has limited value in guiding management of patients with early stage non-small cell carcinoma.

    Original languageEnglish (US)
    Pages (from-to)78-85
    Number of pages8
    JournalCancer
    Volume69
    Issue number1
    StatePublished - 1992

    Fingerprint

    Non-Small Cell Lung Carcinoma
    Neoplasms
    Ploidies
    Recurrence
    Carcinoma
    Registries
    Case-Control Studies
    Multivariate Analysis
    DNA

    ASJC Scopus subject areas

    • Cancer Research
    • Oncology

    Cite this

    Schmidt, R. A., Rusch, V. W., & Piantadosi, S. (1992). A flow cytometric study of non-small cell lung cancer classified as T1NO. Cancer, 69(1), 78-85.

    A flow cytometric study of non-small cell lung cancer classified as T1NO. / Schmidt, R. A.; Rusch, V. W.; Piantadosi, S.

    In: Cancer, Vol. 69, No. 1, 1992, p. 78-85.

    Research output: Contribution to journalArticle

    Schmidt, RA, Rusch, VW & Piantadosi, S 1992, 'A flow cytometric study of non-small cell lung cancer classified as T1NO', Cancer, vol. 69, no. 1, pp. 78-85.
    Schmidt RA, Rusch VW, Piantadosi S. A flow cytometric study of non-small cell lung cancer classified as T1NO. Cancer. 1992;69(1):78-85.
    Schmidt, R. A. ; Rusch, V. W. ; Piantadosi, S. / A flow cytometric study of non-small cell lung cancer classified as T1NO. In: Cancer. 1992 ; Vol. 69, No. 1. pp. 78-85.
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