A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer

Analia Azaro, Jordi Rodon, Antonio Calles, Irene Braña, Manuel Hidalgo, Pedro P. Lopez-Casas, Manuel Munoz, Paul Westwood, Joel Miller, Brian A. Moser, Ute Ohnmacht, William Bumgardner, Karim A. Benhadji, Emiliano Calvo

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Abstract

Summary: The primary objective of this phase I study of LY2780301, a dual p70 S6 kinase and Akt inhibitor, was to determine the recommended phase II dose as a single agent in patients with advanced cancer. Secondary objectives included safety, pharmacokinetic, and pharmacodynamic analyses, and co-clinical analyses in Avatar models. Eligible patients received total daily doses of LY2780301 100-500 mg, given orally as a single dose or divided into 2 doses for 28-day cycles. Dose escalation followed 3+3 design. The primary pharmacodynamic endpoint was inhibition of S6 assessed by skin and tumor biopsy. Thirty-two patients were treated. Common toxicities possibly related to treatment included constipation (19 %), fatigue (13 %), nausea (9 %), and diarrhea (9 %). Grade 3/4 toxicities potentially related to treatment were anemia (n=2), increased alanine aminotransferase/aspartate aminotransferase (ALT) (n=1), and increased gamma-glutamyl transpeptidase (GGT) (n=1). One patient experienced best overall response of prolonged stable disease for 6 cycles. Plasma exposures of LY2780301 exceeded predicted efficacious exposures, but were not dose proportional. Among patients receiving 500 mg daily >50 % exhibited reduced S6 in skin biopsies at Day 8 of treatment, but the effect was not maintained. Plasma concentrations of LY2780301 and/or its metabolites were not correlated with S6 expression in the epidermis. There was minimal antitumor activity against the model, CRC 019. Avatar models showed minimal pharmacodynamic effects consistent with the observed antitumor effects. This study suggests a dose of LY2780301 500 mg QD for future studies.

Original languageEnglish (US)
Pages (from-to)710-719
Number of pages10
JournalInvestigational New Drugs
Volume33
Issue number3
DOIs
StatePublished - Jun 22 2015

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Keywords

  • Akt
  • Cancer
  • LY2780301
  • PI3K/Akt/mTOR signaling pathway
  • mTOR
  • p70 S6 kinase (p70S6K)

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

Cite this

Azaro, A., Rodon, J., Calles, A., Braña, I., Hidalgo, M., Lopez-Casas, P. P., Munoz, M., Westwood, P., Miller, J., Moser, B. A., Ohnmacht, U., Bumgardner, W., Benhadji, K. A., & Calvo, E. (2015). A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer. Investigational New Drugs, 33(3), 710-719. https://doi.org/10.1007/s10637-015-0241-7