A finger photoplethysmography waveform during the valsalva maneuver detects changes in left heart filling pressure after hemodialysis

Panagis Galiatsatos, Kapil Parakh, Jennifer Monti, Sumeska Thavarajah, Harriet Aneke-Ogbu, Amaris Watson, Daniel Kim, Nae Yuh Wang, Tariq Shafi, Harry Silber

Research output: Contribution to journalArticle

Abstract

Background: A noninvasive system for determining left ventricular (LV) filling pressure may help to improve personalized fluid removal goals in hemodialysis patients. We previously showed that the change in photoplethysmography (PPG) pulse amplitude measured by finger PPG during a Valsalva maneuver correlates with invasively measured left ventricular end-diastolic pressure (LVEDP). This key PPG change, the ratio of finger PPG pulse amplitude at end-Valsalva to baseline, is known as the Pulse Amplitude Ratio, PAR. The objective of this study was to determine how PAR changes after fluid removal in hemodialysis. Methods: We tested subjects with end-stage renal disease, before and after hemodialysis. Each subject performed a Valsalva maneuver with an effort of 20 mmHg for 10 s, guided by the device display. Finger PPG was recorded continuously before and during the maneuver. PAR was calculated automatically. Results: Twenty-seven subjects (21 Males) ages 25-75 years were tested. Access sites were AV-fistulas of the arm predominantly. Weight decreased from 99.7 ± 36.9 kg to 97.0 ± 36.0 kg (p <0.0003) with an average fluid removal of 3.07 ± 1.08 l. Correspondingly, PAR decreased from 0.74 ± 0.24 to 0.62 ± 0.23 (p = 0.003). The change in PAR was correlated with baseline PAR (r = 0.48, p = 0.01). Conclusion: An index of left heart filling pressure obtained noninvasively using finger photoplethysmography during the Valsalva maneuver is sensitive enough to detect reductions in filling pressure after fluid removal with hemodialysis. Further studies are warranted to determine if this method can be used to guide fluid removal during hemodialysis.

Original languageEnglish (US)
Article number138
JournalBMC Nephrology
Volume16
Issue number1
DOIs
StatePublished - Aug 14 2015

Fingerprint

Photoplethysmography
Valsalva Maneuver
Fingers
Renal Dialysis
Pressure
Pulse
Ventricular Pressure
Chronic Kidney Failure
Fistula
Arm
Blood Pressure
Weights and Measures
Equipment and Supplies

Keywords

  • Hemodialysis
  • Left ventricular filling pressure
  • Valsalva
  • Volume status

ASJC Scopus subject areas

  • Nephrology

Cite this

A finger photoplethysmography waveform during the valsalva maneuver detects changes in left heart filling pressure after hemodialysis. / Galiatsatos, Panagis; Parakh, Kapil; Monti, Jennifer; Thavarajah, Sumeska; Aneke-Ogbu, Harriet; Watson, Amaris; Kim, Daniel; Wang, Nae Yuh; Shafi, Tariq; Silber, Harry.

In: BMC Nephrology, Vol. 16, No. 1, 138, 14.08.2015.

Research output: Contribution to journalArticle

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AU - Monti, Jennifer

AU - Thavarajah, Sumeska

AU - Aneke-Ogbu, Harriet

AU - Watson, Amaris

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AU - Wang, Nae Yuh

AU - Shafi, Tariq

AU - Silber, Harry

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KW - Volume status

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