A family of Acrp30/adiponectin structural and functional paralogs

Guang William Wong, Jin Wang, Christopher Hug, Tsu Shuen Tsao, Harvey F. Lodish

Research output: Contribution to journalArticle

Abstract

Biochemical, genetic, and animal studies in recent years have established a critical role for the adipokine Acrp30/adiponectin in controlling whole-body metabolism, particularly by enhancing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle. We describe a widely expressed and highly conserved family of adiponectin paralogs designated as C1q/tumor necrosis factor-α-related proteins (CTRPs) 1-7. In the present study, we focus on mCTRP2, the mouse paralog most similar to adiponectin. At nanomolar concentrations, bacterially produced mCTRP2 rapidly induced phosphorylation of AMP-activated protein kinase, acetyl-CoA carboxylase, and mitogen-activated protein kinase in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation. The discovery of a family of adiponectin paralogs has implications for understanding the control of energy homeostasis and could provide new targets for pharmacologic intervention in metabolic diseases such as diabetes and obesity.

Original languageEnglish (US)
Pages (from-to)10302-10307
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number28
DOIs
StatePublished - Jul 13 2004
Externally publishedYes

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Adiponectin
Fatty Acids
Acetyl-CoA Carboxylase
Muscles
AMP-Activated Protein Kinases
Adipokines
Metabolic Diseases
Skeletal Muscle Fibers
Mitogen-Activated Protein Kinases
Glycogen
Insulin Resistance
Molecular Biology
Homeostasis
Tumor Necrosis Factor-alpha
Obesity
Phosphorylation
Liver
Proteins

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

A family of Acrp30/adiponectin structural and functional paralogs. / Wong, Guang William; Wang, Jin; Hug, Christopher; Tsao, Tsu Shuen; Lodish, Harvey F.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 28, 13.07.2004, p. 10302-10307.

Research output: Contribution to journalArticle

Wong, Guang William ; Wang, Jin ; Hug, Christopher ; Tsao, Tsu Shuen ; Lodish, Harvey F. / A family of Acrp30/adiponectin structural and functional paralogs. In: Proceedings of the National Academy of Sciences of the United States of America. 2004 ; Vol. 101, No. 28. pp. 10302-10307.
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