A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia

I. Murad, I. Kremer, M. Dobrusin, M. Muhaheed, I. Bannoura, D. J. Mller, T. G. Schulze, A. Reshef, M. Blanaru, S. Gathas, V. Tsenter, M. Rietschel, R. H. Belmaker, W. Maier, Richard P. Ebstein

Research output: Contribution to journalArticle

Abstract

The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS).

Original languageEnglish (US)
Pages (from-to)236-238
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume105
Issue number3
DOIs
Publication statusPublished - Apr 8 2001
Externally publishedYes

    Fingerprint

Keywords

  • 5HT2C receptor
  • Genetics
  • Polymorphism
  • Schizophrenia
  • Transmission disequilibrium test

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Murad, I., Kremer, I., Dobrusin, M., Muhaheed, M., Bannoura, I., Mller, D. J., ... Ebstein, R. P. (2001). A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics, 105(3), 236-238. https://doi.org/10.1002/ajmg.1260