A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia

I. Murad, I. Kremer, M. Dobrusin, M. Muhaheed, I. Bannoura, D. J. Mller, T. G. Schulze, A. Reshef, M. Blanaru, S. Gathas, V. Tsenter, M. Rietschel, R. H. Belmaker, W. Maier, Richard P. Ebstein

Research output: Contribution to journalArticle

Abstract

The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS).

Original languageEnglish (US)
Pages (from-to)236-238
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume105
Issue number3
DOIs
StatePublished - Apr 8 2001
Externally publishedYes

Fingerprint

Serotonin Receptors
Schizophrenia
Antipsychotic Agents
Alleles
Clozapine
Nuclear Family
Ethnic Groups
Parents
Mothers

Keywords

  • 5HT2C receptor
  • Genetics
  • Polymorphism
  • Schizophrenia
  • Transmission disequilibrium test

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Murad, I., Kremer, I., Dobrusin, M., Muhaheed, M., Bannoura, I., Mller, D. J., ... Ebstein, R. P. (2001). A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics, 105(3), 236-238. https://doi.org/10.1002/ajmg.1260

A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia. / Murad, I.; Kremer, I.; Dobrusin, M.; Muhaheed, M.; Bannoura, I.; Mller, D. J.; Schulze, T. G.; Reshef, A.; Blanaru, M.; Gathas, S.; Tsenter, V.; Rietschel, M.; Belmaker, R. H.; Maier, W.; Ebstein, Richard P.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 105, No. 3, 08.04.2001, p. 236-238.

Research output: Contribution to journalArticle

Murad, I, Kremer, I, Dobrusin, M, Muhaheed, M, Bannoura, I, Mller, DJ, Schulze, TG, Reshef, A, Blanaru, M, Gathas, S, Tsenter, V, Rietschel, M, Belmaker, RH, Maier, W & Ebstein, RP 2001, 'A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 105, no. 3, pp. 236-238. https://doi.org/10.1002/ajmg.1260
Murad, I. ; Kremer, I. ; Dobrusin, M. ; Muhaheed, M. ; Bannoura, I. ; Mller, D. J. ; Schulze, T. G. ; Reshef, A. ; Blanaru, M. ; Gathas, S. ; Tsenter, V. ; Rietschel, M. ; Belmaker, R. H. ; Maier, W. ; Ebstein, Richard P. / A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2001 ; Vol. 105, No. 3. pp. 236-238.
@article{216940240d124166b5dff542d20e0df0,
title = "A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia",
abstract = "The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS).",
keywords = "5HT2C receptor, Genetics, Polymorphism, Schizophrenia, Transmission disequilibrium test",
author = "I. Murad and I. Kremer and M. Dobrusin and M. Muhaheed and I. Bannoura and Mller, {D. J.} and Schulze, {T. G.} and A. Reshef and M. Blanaru and S. Gathas and V. Tsenter and M. Rietschel and Belmaker, {R. H.} and W. Maier and Ebstein, {Richard P.}",
year = "2001",
month = "4",
day = "8",
doi = "10.1002/ajmg.1260",
language = "English (US)",
volume = "105",
pages = "236--238",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia

AU - Murad, I.

AU - Kremer, I.

AU - Dobrusin, M.

AU - Muhaheed, M.

AU - Bannoura, I.

AU - Mller, D. J.

AU - Schulze, T. G.

AU - Reshef, A.

AU - Blanaru, M.

AU - Gathas, S.

AU - Tsenter, V.

AU - Rietschel, M.

AU - Belmaker, R. H.

AU - Maier, W.

AU - Ebstein, Richard P.

PY - 2001/4/8

Y1 - 2001/4/8

N2 - The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS).

AB - The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS).

KW - 5HT2C receptor

KW - Genetics

KW - Polymorphism

KW - Schizophrenia

KW - Transmission disequilibrium test

UR - http://www.scopus.com/inward/record.url?scp=0035826460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035826460&partnerID=8YFLogxK

U2 - 10.1002/ajmg.1260

DO - 10.1002/ajmg.1260

M3 - Article

C2 - 11353441

AN - SCOPUS:0035826460

VL - 105

SP - 236

EP - 238

JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

SN - 1552-4841

IS - 3

ER -