A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia

I. Murad; I. Kremer; M. Dobrusin; M. Muhaheed; I. Bannoura; D. J. Mller; T. G. Schulze; A. Reshef; M. Blanaru; S. Gathas; V. Tsenter; M. Rietschel; R. H. Belmaker; W. Maier; Richard P. Ebstein

doi:10.1002/ajmg.1260

A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia

I. Murad, I. Kremer, M. Dobrusin, M. Muhaheed, I. Bannoura, D. J. Mller, T. G. Schulze, A. Reshef, M. Blanaru, S. Gathas, V. Tsenter, M. Rietschel, R. H. Belmaker, W. Maier, Richard P. Ebstein

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS).

Original language	English (US)
Pages (from-to)	236-238
Number of pages	3
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	105
Issue number	3
DOIs	https://doi.org/10.1002/ajmg.1260
State	Published - Apr 8 2001
Externally published	Yes

Keywords

5HT2C receptor
Genetics
Polymorphism
Schizophrenia
Transmission disequilibrium test

ASJC Scopus subject areas

Genetics(clinical)
Neuropsychology and Physiological Psychology
General Neuroscience

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10.1002/ajmg.1260

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Murad, I., Kremer, I., Dobrusin, M., Muhaheed, M., Bannoura, I., Mller, D. J., Schulze, T. G., Reshef, A., Blanaru, M., Gathas, S., Tsenter, V., Rietschel, M., Belmaker, R. H., Maier, W., & Ebstein, R. P. (2001). A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics, 105(3), 236-238. https://doi.org/10.1002/ajmg.1260

Murad, I, Kremer, I, Dobrusin, M, Muhaheed, M, Bannoura, I, Mller, DJ, Schulze, TG, Reshef, A, Blanaru, M, Gathas, S, Tsenter, V, Rietschel, M, Belmaker, RH, Maier, W & Ebstein, RP 2001, 'A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 105, no. 3, pp. 236-238. https://doi.org/10.1002/ajmg.1260

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A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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