A facile route to paclitaxel C-10 carbamates

Carlo Ballatore, Simon E. Aspland, Rosario Castillo, Joel Desharnais, Trisha Eustaquio, Chengzao Sun, Angelo J. Castellino, Amos B. Smith

Research output: Contribution to journalArticlepeer-review

Abstract

A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2′-O-TBS-7-O-TES- 10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules.

Original languageEnglish (US)
Pages (from-to)2477-2480
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number10
DOIs
StatePublished - May 16 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A facile route to paclitaxel C-10 carbamates'. Together they form a unique fingerprint.

Cite this