A facile route to paclitaxel C-10 carbamates

Carlo Ballatore; Simon Aspland; Rosario Castillo; Joel Desharnais; Trisha Eustaquio; Chengzao Sun; Angelo J. Castellino; Amos B. Smith

doi:10.1016/j.bmcl.2005.03.072

A facile route to paclitaxel C-10 carbamates

Carlo Ballatore, Simon Aspland, Rosario Castillo, Joel Desharnais, Trisha Eustaquio, Chengzao Sun, Angelo J. Castellino, Amos B. Smith

Research output: Contribution to journal › Article

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ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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A facile route to paclitaxel C-10 carbamates. / Ballatore, Carlo; Aspland, Simon; Castillo, Rosario; Desharnais, Joel; Eustaquio, Trisha; Sun, Chengzao; Castellino, Angelo J.; Smith, Amos B.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 10, 16.05.2005, p. 2477-2480.

Research output: Contribution to journal › Article

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title = "A facile route to paclitaxel C-10 carbamates",

abstract = "A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2′-O-TBS-7-O-TES- 10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules.",

author = "Carlo Ballatore and Simon Aspland and Rosario Castillo and Joel Desharnais and Trisha Eustaquio and Chengzao Sun and Castellino, {Angelo J.} and Smith, {Amos B.}",

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AU - Ballatore, Carlo

AU - Aspland, Simon

AU - Castillo, Rosario

AU - Desharnais, Joel

AU - Eustaquio, Trisha

AU - Sun, Chengzao

AU - Castellino, Angelo J.

AU - Smith, Amos B.

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