A facile method for the synthesis of substituted pyrazolo[3,4-c]pyridines

Sharad K. Verma, Louis V. LaFrance

Research output: Contribution to journalArticlepeer-review

Abstract

Methods for a facile high-yielding synthesis of substituted pyrazolo[3,4-c]pyridines from 2-bromo-5-fluoropyridine are described, along with a brief mechanistic discussion for the key cyclization step. The methods utilize inexpensive commercially available starting materials and unlike previous methods, are more suitable for SAR work and scale-up.

Original languageEnglish (US)
Pages (from-to)383-385
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number4
DOIs
StatePublished - Jan 28 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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