Abstract
Methods for a facile high-yielding synthesis of substituted pyrazolo[3,4-c]pyridines from 2-bromo-5-fluoropyridine are described, along with a brief mechanistic discussion for the key cyclization step. The methods utilize inexpensive commercially available starting materials and unlike previous methods, are more suitable for SAR work and scale-up.
Original language | English (US) |
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Pages (from-to) | 383-385 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 50 |
Issue number | 4 |
DOIs | |
State | Published - Jan 28 2009 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry