A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI

Bo Song; Yunkou Wu; Mengxiao Yu; Piyu Zhao; Chen Zhou; Garry E. Kiefer; A. Dean Sherry

doi:10.1039/c3dt50194a

A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI

Bo Song, Yunkou Wu, Mengxiao Yu, Piyu Zhao, Chen Zhou, Garry E. Kiefer, A. Dean Sherry

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A europium(iii) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (¹O₂). The water soluble, thermodynamically stable complex reacts rapidly with ¹O₂ to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(iii)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.

Original language	English (US)
Pages (from-to)	8066-8069
Number of pages	4
Journal	Dalton Transactions
Volume	42
Issue number	22
DOIs	https://doi.org/10.1039/c3dt50194a
State	Published - Jun 14 2013
Externally published	Yes

ASJC Scopus subject areas

Inorganic Chemistry

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abstract = "A europium(iii) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (1O2). The water soluble, thermodynamically stable complex reacts rapidly with 1O2 to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(iii)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.",

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AU - Song, Bo

AU - Wu, Yunkou

AU - Yu, Mengxiao

AU - Zhao, Piyu

AU - Zhou, Chen

AU - Kiefer, Garry E.

AU - Sherry, A. Dean

PY - 2013/6/14

Y1 - 2013/6/14

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AB - A europium(iii) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (1O2). The water soluble, thermodynamically stable complex reacts rapidly with 1O2 to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(iii)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.

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A europium(iii)-based PARACEST agent for sensing singlet oxygen by MRI

Abstract

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