A dual DTI approach to analyzing white matter in children with dyslexia

John C. Carter, Diane C. Lanham, Laurie E. Cutting, Amy M. Clements-Stephens, Xuejing Chen, Muhamed Hadzipasic, Joon Kim, Martha B. Denckla, Walter E. Kaufmann

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalPsychiatry Research - Neuroimaging
Issue number3
StatePublished - Jun 30 2009


  • Anisotropy
  • Reading disability
  • Superior longitudinal fasciculus

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


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