A dual DTI approach to analyzing white matter in children with dyslexia

John C. Carter; Diane C. Lanham; Laurie E. Cutting; Amy M. Clements-Stephens; Xuejing Chen; Muhamed Hadzipasic; Joon Kim; Martha B. Denckla; Walter E. Kaufmann

doi:10.1016/j.pscychresns.2008.09.005

A dual DTI approach to analyzing white matter in children with dyslexia

John C. Carter, Diane C. Lanham, Laurie E. Cutting, Amy M. Clements-Stephens, Xuejing Chen, Muhamed Hadzipasic, Joon Kim, Martha B. Denckla, Walter E. Kaufmann

School of Medicine

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.

Original language	English (US)
Pages (from-to)	215-219
Number of pages	5
Journal	Psychiatry Research - Neuroimaging
Volume	172
Issue number	3
DOIs	https://doi.org/10.1016/j.pscychresns.2008.09.005
State	Published - Jun 30 2009

Keywords

Anisotropy
Reading disability
Superior longitudinal fasciculus

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/j.pscychresns.2008.09.005

Cite this

@article{9e786aaf69ef416ba79de1ce89545998,

title = "A dual DTI approach to analyzing white matter in children with dyslexia",

abstract = "Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.",

keywords = "Anisotropy, Reading disability, Superior longitudinal fasciculus",

author = "Carter, {John C.} and Lanham, {Diane C.} and Cutting, {Laurie E.} and Clements-Stephens, {Amy M.} and Xuejing Chen and Muhamed Hadzipasic and Joon Kim and Denckla, {Martha B.} and Kaufmann, {Walter E.}",

note = "Funding Information: The research reported was supported by NIH grants P50 HD52121, P30 HD24061, P01 HD24448, and the Charles A. Dana Foundation. We thank Dr. S. Mori for the use of his DTI-Studio software, and the children and families who generously participated in this study. ",

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doi = "10.1016/j.pscychresns.2008.09.005",

language = "English (US)",

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T1 - A dual DTI approach to analyzing white matter in children with dyslexia

AU - Carter, John C.

AU - Lanham, Diane C.

AU - Cutting, Laurie E.

AU - Clements-Stephens, Amy M.

AU - Chen, Xuejing

AU - Hadzipasic, Muhamed

AU - Kim, Joon

AU - Denckla, Martha B.

AU - Kaufmann, Walter E.

N1 - Funding Information: The research reported was supported by NIH grants P50 HD52121, P30 HD24061, P01 HD24448, and the Charles A. Dana Foundation. We thank Dr. S. Mori for the use of his DTI-Studio software, and the children and families who generously participated in this study.

PY - 2009/6/30

Y1 - 2009/6/30

N2 - Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.

AB - Using voxel-based (VBA) and region-of-interest (ROI) diffusion tensor imaging (DTI) analyses, we examined white matter (WM) organization in seven children with dyslexia and six age-matched controls. Both methods demonstrated reduced fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF) and abnormal orientation in the right SLF in dyslexics. Application of this complementary dual DTI approach to dyslexia, which included novel analyses of fiber orientation, demonstrates its usefulness for analyzing mild and complex WM abnormalities.

KW - Anisotropy

KW - Reading disability

KW - Superior longitudinal fasciculus

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JO - Psychiatry Research - Neuroimaging

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ER -

A dual DTI approach to analyzing white matter in children with dyslexia

Abstract

Keywords

ASJC Scopus subject areas

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