A DOUBLE‐BLIND CROSSOVER STUDY TO COMPARE LYSINE ACETYL SALICYLATE (ASPERGESIC) WITH IBUPROFEN IN THE TREATMENT OF RHEUMATOID ARTHRITIS

J. Hill; H. A. Bird; G. C. Fenn; C. E. Lee; M. Woodward; V. Wright

doi:10.1111/j.1365-2710.1990.tb00376.x

A DOUBLE‐BLIND CROSSOVER STUDY TO COMPARE LYSINE ACETYL SALICYLATE (ASPERGESIC) WITH IBUPROFEN IN THE TREATMENT OF RHEUMATOID ARTHRITIS

J. Hill, H. A. Bird, G. C. Fenn, C. E. Lee, M. Woodward, V. Wright

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Lysine acetyl salicylate [1 ‐8 g t.d.s. (Aspergesic 1,000 sachet)] has been compared to 400‐mg ibuprofen tablets t.d.s. in a randomized double‐blind trial in patients with rheumatoid arthritis using double‐dummy technique. Both drugs proved effective in relieving symptoms. Three patients experienced drug‐related side‐effects with Aspergesic, and one patient with ibuprofen, that necessitated early discontinuation of treatment. Aspergesic was associated with a greater number of haemoglobin values falling below the normal range than ibuprofen. At the end of the study, eight out of 10 patients who expressed a preference selected Aspergesic for improving mobility whilst 15/24 selected Aspergesic for improving pain.

Original language	English (US)
Pages (from-to)	205-211
Number of pages	7
Journal	Journal of Clinical Pharmacy and Therapeutics
Volume	15
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2710.1990.tb00376.x
State	Published - Jun 1990
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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title = "A DOUBLE‐BLIND CROSSOVER STUDY TO COMPARE LYSINE ACETYL SALICYLATE (ASPERGESIC) WITH IBUPROFEN IN THE TREATMENT OF RHEUMATOID ARTHRITIS",

abstract = "Lysine acetyl salicylate [1 ‐8 g t.d.s. (Aspergesic 1,000 sachet)] has been compared to 400‐mg ibuprofen tablets t.d.s. in a randomized double‐blind trial in patients with rheumatoid arthritis using double‐dummy technique. Both drugs proved effective in relieving symptoms. Three patients experienced drug‐related side‐effects with Aspergesic, and one patient with ibuprofen, that necessitated early discontinuation of treatment. Aspergesic was associated with a greater number of haemoglobin values falling below the normal range than ibuprofen. At the end of the study, eight out of 10 patients who expressed a preference selected Aspergesic for improving mobility whilst 15/24 selected Aspergesic for improving pain.",

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AU - Woodward, M.

AU - Wright, V.

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A DOUBLE‐BLIND CROSSOVER STUDY TO COMPARE LYSINE ACETYL SALICYLATE (ASPERGESIC) WITH IBUPROFEN IN THE TREATMENT OF RHEUMATOID ARTHRITIS

Abstract

ASJC Scopus subject areas

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