A DOUBLE‐BLIND CROSSOVER STUDY TO COMPARE LYSINE ACETYL SALICYLATE (ASPERGESIC) WITH IBUPROFEN IN THE TREATMENT OF RHEUMATOID ARTHRITIS

J. Hill, H. A. Bird, G. C. Fenn, C. E. Lee, M. Woodward, V. Wright

Research output: Contribution to journalArticle

Abstract

Lysine acetyl salicylate [1 ‐8 g t.d.s. (Aspergesic 1,000 sachet)] has been compared to 400‐mg ibuprofen tablets t.d.s. in a randomized double‐blind trial in patients with rheumatoid arthritis using double‐dummy technique. Both drugs proved effective in relieving symptoms. Three patients experienced drug‐related side‐effects with Aspergesic, and one patient with ibuprofen, that necessitated early discontinuation of treatment. Aspergesic was associated with a greater number of haemoglobin values falling below the normal range than ibuprofen. At the end of the study, eight out of 10 patients who expressed a preference selected Aspergesic for improving mobility whilst 15/24 selected Aspergesic for improving pain.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalJournal of Clinical Pharmacy and Therapeutics
Volume15
Issue number3
DOIs
StatePublished - Jun 1990

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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