A double-masked, randomized, placebo-controlled trial of temporary endoscopic mucosal gastric electrical stimulation for gastroparesis

Thomas L. Abell, William D. Johnson, Archana Kedar, J. Matthew Runnels, Janelle Thompson, Ernest S. Weeks, Anil Minocha, Michael E. Griswold

Research output: Contribution to journalArticle

Abstract

Background: Endoscopically placed, temporary gastric electrical stimulation (tGES) may relieve symptoms of gastroparesis (Gp) and predict permanent gastric electrical stimulation (GES) outcomes. Objective: To measure effects of 72 hours of temporary GES on Gp symptoms. Design, Setting, and Patients: From 2005 to 2006, we conducted a hospital-based, randomized, placebo-controlled, crossover trial of two consecutive, 4-day sessions (session 1 and session 2), enrolling 58 patients (11 males, 47 females; mean age 46 years) with GP symptom histories of three etiologies (idiopathic, 38; diabetes mellitus, 13; postsurgical, 7). Intervention: 72 continuous hours temporary GES was provided for group A during session 1, and for group B during session 2. Main Outcome Measurements: Symptoms measured daily; gastric emptying, electrogastrography, and quality of life measured at baseline and session close. Results: In session 1, vomiting decreased in both groups, but was greater with stimulation, resulting in a day 3 difference of -1.02 (95% CI, -1.62 to -0.42; P

Original languageEnglish (US)
JournalGastrointestinal Endoscopy
Volume74
Issue number3
DOIs
StatePublished - Sep 2011
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

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