A double blind trial of the effect of cromolyn sodium on exercise-induced bronchospasm

Peyton A. Eggleston, C. Warren Bierman, William E. Pierson, Stanley J. Stamm, Paul P. Van Arsdel

Research output: Contribution to journalArticlepeer-review

Abstract

Nineteen children with atopic airway disease who had a demonstrable post-exercise decrease in forced expiratory volume in one second (FEV1) using a standardized stress on a cycloergometer were treated with disodium cromoglycate (cromolyn sodium) in a double blind crossover study with a placebo control. Significant reduction of post-exercise bronchospasm was obtained by a single dose of 20 mg. of the drug inhaled one hour before exercise; the effect of the single dose was enhanced if preceded by 3 weeks of daily medication. No side effects were detected during the prolonged use of the drug. The significance of cromolyn's effect on the phenomenon is discussed.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalThe Journal of allergy and clinical immunology
Volume50
Issue number1
DOIs
StatePublished - Jul 1972

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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