A double-blind clinical trial comparing World Health Organization oral rehydration solution with a reduced osmolarity solution containing equal amounts of sodium and glucose

Mathuram Santosham, I. Fayad, M. A. Zikri, A. Hussein, A. Amponsah, C. Duggan, M. Hashem, N. El Sady, M. A. Zikri, O. Fontaine

Research output: Contribution to journalArticle

Abstract

Objective: To compare the safety and efficacy of an oral rehydration solution (ORS) containing 75 mmol/L of sodium and glucose each with the standard World Health Organization (WHO) ORS among Egyptian children with acute diarrhea. Methods: One hundred ninety boys, aged 1 to 24 months, who were admitted to the hospital with acute diarrhea and signs of dehydration were randomly assigned to receive either standard ORS (311 mmol/L) or a reduced osmolarity ORS (245 mmol/L). Intake and output were measured every 3 hours. Results: In the group treated with reduced osmolarity ORS, the mean stool output during the rehydration phase was 36% lower (95% confidence interval, 1%, 100%) than in those treated with WHO ORS. The relative risk of vomiting during the rehydration phase was significantly lower in children treated with reduced osmolarity ORS (relative risk, 2.4; 95% confidence interval, 1.2, 4.8). During the maintenance phase, stool output, mean intake of food and ORS, duration of diarrhea, and weight gain were similar in the treatment groups. The relative risk of treatment failure (need for unscheduled administration of intravenous fluids) was significantly increased in children receiving standard WHO ORS (relative risk, 7.9; 95% confidence Interval, 1.1, 60.9). The mean serum sodium concentration at 24 hours was significantly lower in children receiving the reduced osmolarity ORS solution (134 ± 6 mEq/L) than in children receiving the standard WHO ORS (138 ± 7 mEq/L) (p

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalJournal of Pediatrics
Volume128
Issue number1
DOIs
StatePublished - 1996

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Fluid Therapy
Rehydration Solutions
Osmolar Concentration
Sodium
Clinical Trials
Glucose
Diarrhea
Confidence Intervals
World Health Organization oral rehydration solution
Treatment Failure
Dehydration
Intravenous Administration
Weight Gain
Vomiting
Eating
Maintenance
Safety

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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A double-blind clinical trial comparing World Health Organization oral rehydration solution with a reduced osmolarity solution containing equal amounts of sodium and glucose. / Santosham, Mathuram; Fayad, I.; Zikri, M. A.; Hussein, A.; Amponsah, A.; Duggan, C.; Hashem, M.; El Sady, N.; Zikri, M. A.; Fontaine, O.

In: Journal of Pediatrics, Vol. 128, No. 1, 1996, p. 45-51.

Research output: Contribution to journalArticle

Santosham, Mathuram ; Fayad, I. ; Zikri, M. A. ; Hussein, A. ; Amponsah, A. ; Duggan, C. ; Hashem, M. ; El Sady, N. ; Zikri, M. A. ; Fontaine, O. / A double-blind clinical trial comparing World Health Organization oral rehydration solution with a reduced osmolarity solution containing equal amounts of sodium and glucose. In: Journal of Pediatrics. 1996 ; Vol. 128, No. 1. pp. 45-51.
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AU - Zikri, M. A.

AU - Hussein, A.

AU - Amponsah, A.

AU - Duggan, C.

AU - Hashem, M.

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AU - Zikri, M. A.

AU - Fontaine, O.

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