A DNA integrity network in the yeast Saccharomyces cerevisiae

Xuewen Pan, Ping Ye, Daniel S. Yuan, Xiaoling Wang, Joel S. Bader, Jef D. Boeke

Research output: Contribution to journalArticle

Abstract

A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians against lethal spontaneous DNA damage, efficient repair of which requires the functions of the DNA-damage checkpoint signaling and multiple DNA-repair pathways. This genome-wide genetic interaction network also identified novel components (DIA2, NPT1, HST3, HST4, and the CSM1 module) that potentially contribute to mitotic DNA replication and genomic stability and revealed novel functions of well-studied genes (the CTF18 module) in DRC signaling. This network will guide more detailed characterization of mechanisms governing DNA integrity in yeast and other organisms.

Original languageEnglish (US)
Pages (from-to)1069-1081
Number of pages13
JournalCell
Volume124
Issue number5
DOIs
StatePublished - Mar 10 2006

Fingerprint

DNA Replication
Yeast
Saccharomyces cerevisiae
Yeasts
Gene Regulatory Networks
DNA
DNA Damage
Genomic Instability
Genes
DNA Repair
Oxidative Stress
Genome
Repair
Oxidative stress
Defects

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Pan, X., Ye, P., Yuan, D. S., Wang, X., Bader, J. S., & Boeke, J. D. (2006). A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell, 124(5), 1069-1081. https://doi.org/10.1016/j.cell.2005.12.036

A DNA integrity network in the yeast Saccharomyces cerevisiae. / Pan, Xuewen; Ye, Ping; Yuan, Daniel S.; Wang, Xiaoling; Bader, Joel S.; Boeke, Jef D.

In: Cell, Vol. 124, No. 5, 10.03.2006, p. 1069-1081.

Research output: Contribution to journalArticle

Pan, X, Ye, P, Yuan, DS, Wang, X, Bader, JS & Boeke, JD 2006, 'A DNA integrity network in the yeast Saccharomyces cerevisiae', Cell, vol. 124, no. 5, pp. 1069-1081. https://doi.org/10.1016/j.cell.2005.12.036
Pan X, Ye P, Yuan DS, Wang X, Bader JS, Boeke JD. A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell. 2006 Mar 10;124(5):1069-1081. https://doi.org/10.1016/j.cell.2005.12.036
Pan, Xuewen ; Ye, Ping ; Yuan, Daniel S. ; Wang, Xiaoling ; Bader, Joel S. ; Boeke, Jef D. / A DNA integrity network in the yeast Saccharomyces cerevisiae. In: Cell. 2006 ; Vol. 124, No. 5. pp. 1069-1081.
@article{c42cf014735c47ceacbb8f3505306198,
title = "A DNA integrity network in the yeast Saccharomyces cerevisiae",
abstract = "A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians against lethal spontaneous DNA damage, efficient repair of which requires the functions of the DNA-damage checkpoint signaling and multiple DNA-repair pathways. This genome-wide genetic interaction network also identified novel components (DIA2, NPT1, HST3, HST4, and the CSM1 module) that potentially contribute to mitotic DNA replication and genomic stability and revealed novel functions of well-studied genes (the CTF18 module) in DRC signaling. This network will guide more detailed characterization of mechanisms governing DNA integrity in yeast and other organisms.",
author = "Xuewen Pan and Ping Ye and Yuan, {Daniel S.} and Xiaoling Wang and Bader, {Joel S.} and Boeke, {Jef D.}",
year = "2006",
month = "3",
day = "10",
doi = "10.1016/j.cell.2005.12.036",
language = "English (US)",
volume = "124",
pages = "1069--1081",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - A DNA integrity network in the yeast Saccharomyces cerevisiae

AU - Pan, Xuewen

AU - Ye, Ping

AU - Yuan, Daniel S.

AU - Wang, Xiaoling

AU - Bader, Joel S.

AU - Boeke, Jef D.

PY - 2006/3/10

Y1 - 2006/3/10

N2 - A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians against lethal spontaneous DNA damage, efficient repair of which requires the functions of the DNA-damage checkpoint signaling and multiple DNA-repair pathways. This genome-wide genetic interaction network also identified novel components (DIA2, NPT1, HST3, HST4, and the CSM1 module) that potentially contribute to mitotic DNA replication and genomic stability and revealed novel functions of well-studied genes (the CTF18 module) in DRC signaling. This network will guide more detailed characterization of mechanisms governing DNA integrity in yeast and other organisms.

AB - A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians against lethal spontaneous DNA damage, efficient repair of which requires the functions of the DNA-damage checkpoint signaling and multiple DNA-repair pathways. This genome-wide genetic interaction network also identified novel components (DIA2, NPT1, HST3, HST4, and the CSM1 module) that potentially contribute to mitotic DNA replication and genomic stability and revealed novel functions of well-studied genes (the CTF18 module) in DRC signaling. This network will guide more detailed characterization of mechanisms governing DNA integrity in yeast and other organisms.

UR - http://www.scopus.com/inward/record.url?scp=33644778778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644778778&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2005.12.036

DO - 10.1016/j.cell.2005.12.036

M3 - Article

VL - 124

SP - 1069

EP - 1081

JO - Cell

JF - Cell

SN - 0092-8674

IS - 5

ER -