Abstract
In vertebrates, peripheral chemosensory neurons express large families of G protein-coupled receptors (GPCRs), reflecting the diversity and specificity of stimuli they detect. However, somatosensory neurons, which respond to chemical, thermal, or mechanical stimuli, are more broadly tuned. Here we describe a family of approximately 50 GPCRs related to Mas1, called mrgs, a subset of which is expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of mrgs thus reveal an unexpected degree of molecular diversity among nociceptive neurons. Some of these receptors can be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF, which are analgesic in vivo. Thus, mrgs may regulate nociceptor function and/or development, including the sensation or modulation of pain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 619-632 |
| Number of pages | 14 |
| Journal | Cell |
| Volume | 106 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 7 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
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A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. / Dong, Xinzhong; Han, Sang kyou; Zylka, Mark J.; Simon, Melvin I.; Anderson, David J.
In: Cell, Vol. 106, No. 5, 07.09.2001, p. 619-632.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons
AU - Dong, Xinzhong
AU - Han, Sang kyou
AU - Zylka, Mark J.
AU - Simon, Melvin I.
AU - Anderson, David J.
PY - 2001/9/7
Y1 - 2001/9/7
N2 - In vertebrates, peripheral chemosensory neurons express large families of G protein-coupled receptors (GPCRs), reflecting the diversity and specificity of stimuli they detect. However, somatosensory neurons, which respond to chemical, thermal, or mechanical stimuli, are more broadly tuned. Here we describe a family of approximately 50 GPCRs related to Mas1, called mrgs, a subset of which is expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of mrgs thus reveal an unexpected degree of molecular diversity among nociceptive neurons. Some of these receptors can be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF, which are analgesic in vivo. Thus, mrgs may regulate nociceptor function and/or development, including the sensation or modulation of pain.
AB - In vertebrates, peripheral chemosensory neurons express large families of G protein-coupled receptors (GPCRs), reflecting the diversity and specificity of stimuli they detect. However, somatosensory neurons, which respond to chemical, thermal, or mechanical stimuli, are more broadly tuned. Here we describe a family of approximately 50 GPCRs related to Mas1, called mrgs, a subset of which is expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of mrgs thus reveal an unexpected degree of molecular diversity among nociceptive neurons. Some of these receptors can be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF, which are analgesic in vivo. Thus, mrgs may regulate nociceptor function and/or development, including the sensation or modulation of pain.
UR - http://www.scopus.com/inward/record.url?scp=0035822998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035822998&partnerID=8YFLogxK
U2 - 10.1016/S0092-8674(01)00483-4
DO - 10.1016/S0092-8674(01)00483-4
M3 - Article
C2 - 11551509
AN - SCOPUS:0035822998
VL - 106
SP - 619
EP - 632
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -