A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons

Xinzhong Dong, Sang kyou Han, Mark J. Zylka, Melvin I. Simon, David J. Anderson

Research output: Contribution to journalArticle

Abstract

In vertebrates, peripheral chemosensory neurons express large families of G protein-coupled receptors (GPCRs), reflecting the diversity and specificity of stimuli they detect. However, somatosensory neurons, which respond to chemical, thermal, or mechanical stimuli, are more broadly tuned. Here we describe a family of approximately 50 GPCRs related to Mas1, called mrgs, a subset of which is expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of mrgs thus reveal an unexpected degree of molecular diversity among nociceptive neurons. Some of these receptors can be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF, which are analgesic in vivo. Thus, mrgs may regulate nociceptor function and/or development, including the sensation or modulation of pain.

Original languageEnglish (US)
Pages (from-to)619-632
Number of pages14
JournalCell
Volume106
Issue number5
DOIs
StatePublished - Sep 7 2001
Externally publishedYes

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Nociceptors
Sensory Receptor Cells
G-Protein-Coupled Receptors
Neurons
Neuropeptides
Analgesics
Vertebrates
Hot Temperature
Pain
Modulation
phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide
arginylphenylalaninamide

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. / Dong, Xinzhong; Han, Sang kyou; Zylka, Mark J.; Simon, Melvin I.; Anderson, David J.

In: Cell, Vol. 106, No. 5, 07.09.2001, p. 619-632.

Research output: Contribution to journalArticle

Dong, Xinzhong ; Han, Sang kyou ; Zylka, Mark J. ; Simon, Melvin I. ; Anderson, David J. / A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. In: Cell. 2001 ; Vol. 106, No. 5. pp. 619-632.
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