A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation

Pedram Argani, Anita Hawkins, Constance A. Griffin, Jeffrey D. Goldstein, Mark Haas, J. Bruce Beckwith, Carl B. Mankinen, Elizabeth J. Perlman

Research output: Contribution to journalArticle

Abstract

We report two cases of a hitherto undescribed pediatric renal neoplasm that is distinctive at the morphological, immunohistochemical, ultrastructural, and cytogenetic levels. On light microscopy, the tumors are composed of nests of polygonal, clear to eosinophilic cells associated with a subpopulation of smaller cells that surround hyaline material. Despite their epithelioid morphology, these tumors do not label immunohistochemically for epithelial markers but instead label focally for melanocytic markers HMB45 and Melan A. The hyaline material is positive with periodic acid-Schiff and methenamine-silver histochemical stains, and labels immunohistochemically for type 4 collagen. Ultrastructural examination confirms that it represents basement membrane material. Cytogenetic analysis reveals the identical t(6; 11)(p21.1;q12) chromosome translocation as the sole abnormality in these two tumors, confirming their identity and distinctive nature.

Original languageEnglish (US)
Pages (from-to)2089-2096
Number of pages8
JournalAmerican Journal of Pathology
Volume158
Issue number6
StatePublished - 2001

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Kidney Neoplasms
Basement Membrane
Hyalin
Chromosomes
Pediatrics
MART-1 Antigen
Methenamine
Neoplasms
Periodic Acid
Collagen Type IV
Cytogenetic Analysis
Cytogenetics
Microscopy
Coloring Agents
Light

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation. / Argani, Pedram; Hawkins, Anita; Griffin, Constance A.; Goldstein, Jeffrey D.; Haas, Mark; Beckwith, J. Bruce; Mankinen, Carl B.; Perlman, Elizabeth J.

In: American Journal of Pathology, Vol. 158, No. 6, 2001, p. 2089-2096.

Research output: Contribution to journalArticle

Argani, Pedram ; Hawkins, Anita ; Griffin, Constance A. ; Goldstein, Jeffrey D. ; Haas, Mark ; Beckwith, J. Bruce ; Mankinen, Carl B. ; Perlman, Elizabeth J. / A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation. In: American Journal of Pathology. 2001 ; Vol. 158, No. 6. pp. 2089-2096.
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AU - Griffin, Constance A.

AU - Goldstein, Jeffrey D.

AU - Haas, Mark

AU - Beckwith, J. Bruce

AU - Mankinen, Carl B.

AU - Perlman, Elizabeth J.

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