A discriminative two-lever test of dizocilpine's ability to reinstate ethanol-seeking behavior

Peter S. Vosler; Joan C. Bombace; Therese A. Kosten

doi:10.1016/S0024-3205(01)01150-X

A discriminative two-lever test of dizocilpine's ability to reinstate ethanol-seeking behavior

Peter S. Vosler, Joan C. Bombace, Therese A. Kosten

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Because ethanol has N-methyl-D-aspartate (NMDA) antagonist effects, we tested whether dizocilpine, an NMDA antagonist, reinstates ethanol-seeking behavior. Rats were trained to lever-press for a 10% ethanol/2% sucrose (EtOH) or a 3% sucrose (Suc) solution using a two-lever (one lever active) procedure (FR2). After extinction, rats were injected with ethanol (0.5 g/kg). The EtOH group emitted more active than inactive lever presses and the Suc group showed minimal responding. Thus, ethanol reinstated ethanol-seeking behavior in a specific manner. In contrast, dizocilpine (0.175 mg/kg) increased responding on both levers in both groups suggesting a loss of discriminative control. Dizocilpine fails to reinstate ethanol-seeking behavior. These data also demonstrate the necessity of using a discriminative, two-lever test for drug reinstatement.

Original language	English (US)
Pages (from-to)	591-598
Number of pages	8
Journal	Life Sciences
Volume	69
Issue number	5
DOIs	https://doi.org/10.1016/S0024-3205(01)01150-X
State	Published - Jun 22 2001
Externally published	Yes

Keywords

Alcohol self-administration
NMDA antagonist
Rat
Relapse

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(01)01150-X

Cite this

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title = "A discriminative two-lever test of dizocilpine's ability to reinstate ethanol-seeking behavior",

abstract = "Because ethanol has N-methyl-D-aspartate (NMDA) antagonist effects, we tested whether dizocilpine, an NMDA antagonist, reinstates ethanol-seeking behavior. Rats were trained to lever-press for a 10% ethanol/2% sucrose (EtOH) or a 3% sucrose (Suc) solution using a two-lever (one lever active) procedure (FR2). After extinction, rats were injected with ethanol (0.5 g/kg). The EtOH group emitted more active than inactive lever presses and the Suc group showed minimal responding. Thus, ethanol reinstated ethanol-seeking behavior in a specific manner. In contrast, dizocilpine (0.175 mg/kg) increased responding on both levers in both groups suggesting a loss of discriminative control. Dizocilpine fails to reinstate ethanol-seeking behavior. These data also demonstrate the necessity of using a discriminative, two-lever test for drug reinstatement.",

keywords = "Alcohol self-administration, NMDA antagonist, Rat, Relapse",

author = "Vosler, {Peter S.} and Bombace, {Joan C.} and Kosten, {Therese A.}",

note = "Funding Information: This work was supported by a National Institute on Drug Abuse grant (DA09994) to TAK, by the Abraham Ribicoff Facilities, State of Connecticut, and by an Interdisciplinary Research Grant from Quinnipiac University to PSV. The authors thank B. McMahon, H. Nadim, and J. Spencer for their assistance and Dr. Peter Jatlow in whose laboratory the plasma assays were conducted.",

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AU - Kosten, Therese A.

N1 - Funding Information: This work was supported by a National Institute on Drug Abuse grant (DA09994) to TAK, by the Abraham Ribicoff Facilities, State of Connecticut, and by an Interdisciplinary Research Grant from Quinnipiac University to PSV. The authors thank B. McMahon, H. Nadim, and J. Spencer for their assistance and Dr. Peter Jatlow in whose laboratory the plasma assays were conducted.

PY - 2001/6/22

Y1 - 2001/6/22

N2 - Because ethanol has N-methyl-D-aspartate (NMDA) antagonist effects, we tested whether dizocilpine, an NMDA antagonist, reinstates ethanol-seeking behavior. Rats were trained to lever-press for a 10% ethanol/2% sucrose (EtOH) or a 3% sucrose (Suc) solution using a two-lever (one lever active) procedure (FR2). After extinction, rats were injected with ethanol (0.5 g/kg). The EtOH group emitted more active than inactive lever presses and the Suc group showed minimal responding. Thus, ethanol reinstated ethanol-seeking behavior in a specific manner. In contrast, dizocilpine (0.175 mg/kg) increased responding on both levers in both groups suggesting a loss of discriminative control. Dizocilpine fails to reinstate ethanol-seeking behavior. These data also demonstrate the necessity of using a discriminative, two-lever test for drug reinstatement.

AB - Because ethanol has N-methyl-D-aspartate (NMDA) antagonist effects, we tested whether dizocilpine, an NMDA antagonist, reinstates ethanol-seeking behavior. Rats were trained to lever-press for a 10% ethanol/2% sucrose (EtOH) or a 3% sucrose (Suc) solution using a two-lever (one lever active) procedure (FR2). After extinction, rats were injected with ethanol (0.5 g/kg). The EtOH group emitted more active than inactive lever presses and the Suc group showed minimal responding. Thus, ethanol reinstated ethanol-seeking behavior in a specific manner. In contrast, dizocilpine (0.175 mg/kg) increased responding on both levers in both groups suggesting a loss of discriminative control. Dizocilpine fails to reinstate ethanol-seeking behavior. These data also demonstrate the necessity of using a discriminative, two-lever test for drug reinstatement.

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A discriminative two-lever test of dizocilpine's ability to reinstate ethanol-seeking behavior

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