A diagnostic index of active demyelination: Myelin basic protein in cerebrospinal fluid

S. R. Cohen, B. R. Brooks, R. M. Herndon, G. M. McKhan

Research output: Contribution to journalArticle

Abstract

We have developed a radioimmunoassay to measure a specific neurological component, the basic protein of myelin, and have used this test for assessing this component in spinal fluid. The levels of basic protein in spinal fluid correlate closely with the clinical activity of multiple sclerosis; therefore the test can be used for objective evaluation of disease activity in patients with that disorder. Moreover, it is a useful adjunct in the diagnosis of multiple sclerosis and evaluation of potential therapy. In addition, the test is helpful in diagnosing other diseases in which acute breakdown of myelin occurs, especially leukoencephalopathy resulting from irradiation and chemotherapy for treatment of leukemia in children.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalAnnals of Neurology
Volume8
Issue number1
StatePublished - 1980

Fingerprint

Myelin Basic Protein
Demyelinating Diseases
Multiple Sclerosis
Cerebrospinal Fluid
Leukoencephalopathies
Myelin Sheath
Radioimmunoassay
Leukemia
Drug Therapy
Therapeutics
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cohen, S. R., Brooks, B. R., Herndon, R. M., & McKhan, G. M. (1980). A diagnostic index of active demyelination: Myelin basic protein in cerebrospinal fluid. Annals of Neurology, 8(1), 25-31.

A diagnostic index of active demyelination : Myelin basic protein in cerebrospinal fluid. / Cohen, S. R.; Brooks, B. R.; Herndon, R. M.; McKhan, G. M.

In: Annals of Neurology, Vol. 8, No. 1, 1980, p. 25-31.

Research output: Contribution to journalArticle

Cohen, SR, Brooks, BR, Herndon, RM & McKhan, GM 1980, 'A diagnostic index of active demyelination: Myelin basic protein in cerebrospinal fluid', Annals of Neurology, vol. 8, no. 1, pp. 25-31.
Cohen, S. R. ; Brooks, B. R. ; Herndon, R. M. ; McKhan, G. M. / A diagnostic index of active demyelination : Myelin basic protein in cerebrospinal fluid. In: Annals of Neurology. 1980 ; Vol. 8, No. 1. pp. 25-31.
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