A dextran-based probe for the targeted magnetic resonance imaging of tumours expressing prostate-specific membrane antigen

Guanshu Liu, Sangeeta Ray, Xing Yang, Nirbhay Yadav, Ala Lisok, Anna Jablonska, Jiadi Xu, Yuguo Li, Martin Gilbert Pomper, Peter C Van Zijl

Research output: Contribution to journalArticle

Abstract

Safe imaging agents that are able to render the expression and distribution of cancer receptors, enzymes or other biomarkers would facilitate clinical screening of the disease. Here, we show that diamagnetic dextran particles that are coordinated to a urea-based targeting ligand for prostate-specific membrane antigen (PSMA) enable targeted magnetic resonance imaging (MRI) of the PSMA receptor. In a xenograft model of prostate cancer, micromolar concentrations of the dextran-ligand probe provided sufficient signal to specifically detect PSMA-expressing tumours via chemical exchange saturation transfer MRI. The dextran-based probe could be detected via the contrast that originated from dextran hydroxyl protons, thereby avoiding the need of chemical substitution for radioactive or metallic labelling. Because dextrans are currently used clinically, dextran-based contrast agents may help to extend receptor-targeted imaging to clinical MRI.

Original languageEnglish (US)
Pages (from-to)977-982
Number of pages6
JournalNature Biomedical Engineering
Volume1
Issue number12
DOIs
StatePublished - Dec 1 2017

Fingerprint

Dextran
Magnetic resonance
Antigens
Dextrans
Tumors
Magnetic Resonance Imaging
Membranes
Imaging techniques
Neoplasms
Ligands
Antigen Receptors
Biomarkers
Heterografts
Urea
Hydroxyl Radical
Labeling
Contrast Media
human glutamate carboxypeptidase II
Protons
Prostatic Neoplasms

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Computer Science Applications

Cite this

@article{dc09b1441c414b75b68457eb452339f5,
title = "A dextran-based probe for the targeted magnetic resonance imaging of tumours expressing prostate-specific membrane antigen",
abstract = "Safe imaging agents that are able to render the expression and distribution of cancer receptors, enzymes or other biomarkers would facilitate clinical screening of the disease. Here, we show that diamagnetic dextran particles that are coordinated to a urea-based targeting ligand for prostate-specific membrane antigen (PSMA) enable targeted magnetic resonance imaging (MRI) of the PSMA receptor. In a xenograft model of prostate cancer, micromolar concentrations of the dextran-ligand probe provided sufficient signal to specifically detect PSMA-expressing tumours via chemical exchange saturation transfer MRI. The dextran-based probe could be detected via the contrast that originated from dextran hydroxyl protons, thereby avoiding the need of chemical substitution for radioactive or metallic labelling. Because dextrans are currently used clinically, dextran-based contrast agents may help to extend receptor-targeted imaging to clinical MRI.",
author = "Guanshu Liu and Sangeeta Ray and Xing Yang and Nirbhay Yadav and Ala Lisok and Anna Jablonska and Jiadi Xu and Yuguo Li and Pomper, {Martin Gilbert} and {Van Zijl}, {Peter C}",
year = "2017",
month = "12",
day = "1",
doi = "10.1038/s41551-017-0168-8",
language = "English (US)",
volume = "1",
pages = "977--982",
journal = "Nature Biomedical Engineering",
issn = "2157-846X",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - A dextran-based probe for the targeted magnetic resonance imaging of tumours expressing prostate-specific membrane antigen

AU - Liu, Guanshu

AU - Ray, Sangeeta

AU - Yang, Xing

AU - Yadav, Nirbhay

AU - Lisok, Ala

AU - Jablonska, Anna

AU - Xu, Jiadi

AU - Li, Yuguo

AU - Pomper, Martin Gilbert

AU - Van Zijl, Peter C

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Safe imaging agents that are able to render the expression and distribution of cancer receptors, enzymes or other biomarkers would facilitate clinical screening of the disease. Here, we show that diamagnetic dextran particles that are coordinated to a urea-based targeting ligand for prostate-specific membrane antigen (PSMA) enable targeted magnetic resonance imaging (MRI) of the PSMA receptor. In a xenograft model of prostate cancer, micromolar concentrations of the dextran-ligand probe provided sufficient signal to specifically detect PSMA-expressing tumours via chemical exchange saturation transfer MRI. The dextran-based probe could be detected via the contrast that originated from dextran hydroxyl protons, thereby avoiding the need of chemical substitution for radioactive or metallic labelling. Because dextrans are currently used clinically, dextran-based contrast agents may help to extend receptor-targeted imaging to clinical MRI.

AB - Safe imaging agents that are able to render the expression and distribution of cancer receptors, enzymes or other biomarkers would facilitate clinical screening of the disease. Here, we show that diamagnetic dextran particles that are coordinated to a urea-based targeting ligand for prostate-specific membrane antigen (PSMA) enable targeted magnetic resonance imaging (MRI) of the PSMA receptor. In a xenograft model of prostate cancer, micromolar concentrations of the dextran-ligand probe provided sufficient signal to specifically detect PSMA-expressing tumours via chemical exchange saturation transfer MRI. The dextran-based probe could be detected via the contrast that originated from dextran hydroxyl protons, thereby avoiding the need of chemical substitution for radioactive or metallic labelling. Because dextrans are currently used clinically, dextran-based contrast agents may help to extend receptor-targeted imaging to clinical MRI.

UR - http://www.scopus.com/inward/record.url?scp=85037863113&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037863113&partnerID=8YFLogxK

U2 - 10.1038/s41551-017-0168-8

DO - 10.1038/s41551-017-0168-8

M3 - Article

C2 - 29456877

AN - SCOPUS:85037863113

VL - 1

SP - 977

EP - 982

JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

SN - 2157-846X

IS - 12

ER -