TY - JOUR
T1 - A Description of Risk Factors for Non-alcoholic Fatty Liver Disease in the Southern Community Cohort Study
T2 - A Nested Case-Control Study
AU - Sarkar, Sudipa
AU - Lipworth, Loren
AU - Kabagambe, Edmond K.
AU - Bian, Aihua
AU - Stewart, Thomas G.
AU - Blot, William J.
AU - Ikizler, T. Alp
AU - Hung, Adriana M.
N1 - Funding Information:
Funding. This study was supported by grants from the National Cancer Institute (R01 CA092447), the American Recovery and Reinvestment Act (3R01 CA092447-08S1), the National Institutes of Health (T32 DK007569), and the National Institute of Diabetes and Digestive Diseases (K24 DK62849), a Veterans Affairs Merit Award (1I01CX000982-01A1), and institutional funds from the Vanderbilt Center for Kidney Disease, a National Institutes of Health George O'Brien Kidney and Urological Disease grant, and the Vanderbilt Epidemiology Center.
Publisher Copyright:
© Copyright © 2020 Sarkar, Lipworth, Kabagambe, Bian, Stewart, Blot, Ikizler and Hung.
PY - 2020/5/21
Y1 - 2020/5/21
N2 - Background: Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and hypercholesterolemia. In addition, total fat and folate intake have been associated with NAFLD. Aims: We investigated risk factors for NAFLD among individuals of largely low socioeconomic status, and whether these associations differed by race. Methods: A nested case-control study was conducted within the Southern Community Cohort Study. Through linkage of the cohort with Centers for Medicare and Medicaid Services, International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to identify incident NAFLD cases. Controls were matched 4:1 to cases on enrollment age, sex, and race. A logistic regression was used to estimate odds ratios for the associations of NAFLD with covariates of interest. Results: Neither total fat nor folate intake was significantly associated with NAFLD. Hypercholesterolemia (odds ratio 1.21) and body mass index (75th vs. 25th percentile) for blacks (odds ratio 1.96) and whites (odds ratio 2.33) were associated with an increased risk of non-alcoholic fatty liver disease. No significant interaction with race for any of the studied variables was noted. Conclusions: Both hypercholesterolemia and increasing body mass index, but not total fat and folate intake, were risk factors for NAFLD in the Southern Community Cohort Study.
AB - Background: Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and hypercholesterolemia. In addition, total fat and folate intake have been associated with NAFLD. Aims: We investigated risk factors for NAFLD among individuals of largely low socioeconomic status, and whether these associations differed by race. Methods: A nested case-control study was conducted within the Southern Community Cohort Study. Through linkage of the cohort with Centers for Medicare and Medicaid Services, International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to identify incident NAFLD cases. Controls were matched 4:1 to cases on enrollment age, sex, and race. A logistic regression was used to estimate odds ratios for the associations of NAFLD with covariates of interest. Results: Neither total fat nor folate intake was significantly associated with NAFLD. Hypercholesterolemia (odds ratio 1.21) and body mass index (75th vs. 25th percentile) for blacks (odds ratio 1.96) and whites (odds ratio 2.33) were associated with an increased risk of non-alcoholic fatty liver disease. No significant interaction with race for any of the studied variables was noted. Conclusions: Both hypercholesterolemia and increasing body mass index, but not total fat and folate intake, were risk factors for NAFLD in the Southern Community Cohort Study.
KW - ethnicity
KW - low socioeconomic status
KW - macronutrients
KW - micronutrients
KW - non-alcoholic fatty liver disease
UR - http://www.scopus.com/inward/record.url?scp=85085879914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085879914&partnerID=8YFLogxK
U2 - 10.3389/fnut.2020.00071
DO - 10.3389/fnut.2020.00071
M3 - Article
C2 - 32671089
AN - SCOPUS:85085879914
VL - 7
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
SN - 2296-861X
M1 - 71
ER -