A derived and validated score to predict prolonged mechanical ventilation in patients undergoing cardiac surgery

Vivek Sharma, Vivek Rao, Cedric Manlhiot, Audrey Boruvka, Stephen Fremes, Marcin Wąsowicz

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives Prolonged mechanical ventilation after cardiac surgery imposes a significant burden on the patient in terms of morbidity as well as a financial burden on the hospital. We undertook a retrospective analysis of 2 prospectively collected databases developed in tertiary cardiac care centers to derive and validate a risk index predicting prolonged mechanical ventilation after cardiac surgery. Methods We studied a retrospective cohort of 32,045 patients undergoing cardiac surgery in 2 hospitals in Toronto, Canada. The development cohort consisted of 21,661 patients at Toronto General Hospital. Data Sunnybrook Health Sciences Centre, Toronto, Canada, with 10,384 patients, served as an institutional validation cohort. We operationally characterized prolonged mechanical ventilation as the duration from surgery completion to extubation exceeding 48 hours. Results Prolonged postoperative mechanical ventilation rates in the development and validation cohort were 6% and 7%, respectively. Multivariable regression in the development cohort showed that the following factors were strong predictors of prolonged mechanical ventilation after cardiac surgery: previous cardiac surgery, lower left ventricular ejection fraction, shock, surgery involving repair of congenital heart disease, and cardiopulmonary bypass time. The intraoperative multivariable model retained good discrimination in the validation cohort, achieving a c statistic of 0.787. Conclusions Prolonged mechanical ventilation after cardiac surgery can be accurately predicted by readily available pre- and intraoperative information.

Original languageEnglish (US)
Pages (from-to)108-115
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume153
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • cardiac surgery
  • prolonged mechanical ventilation
  • validated model

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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