A derivative of a rigid glutamate analog protects the retina from excitotoxicity

Renata Siliprandi, Maria Lipartiti, Emanuela Fadda, Roberto Arban, Alan P. Kozikowski, Hari Manev

Research output: Contribution to journalArticle

Abstract

In the retina, the activation of metabotropic glutamate receptors (mGluRs) reduces the toxic effect of N-methyl-D-aspartate (NMDA). We have induced NMDA-mediated excitotoxicity in the adult rat retina by a single intraocular injection of NMDA. The damage that resulted was estimated by assessing the NMDA-induced loss of retinal choline acetyltransferase (ChAT) activity. The new rigid glutamate analog, dimethyl ester of (+/-)-trans-azetidine-2, 4-dicarboxylic acid (t-DMADA), with a putative mGluR-agonistic activity, protected the retina from NMDA-induced loss of ChAT activity. This study demonstrated that t-DMADA can be considered a prototype of new retino-protective agents.

Original languageEnglish (US)
Pages (from-to)1227-1229
Number of pages3
JournalNeuroReport
Volume5
Issue number10
StatePublished - 1994
Externally publishedYes

Fingerprint

N-Methylaspartate
Retina
Glutamic Acid
Choline O-Acetyltransferase
Intraocular Injections
Protective Agents
Metabotropic Glutamate Receptors
Poisons

Keywords

  • Azetidine
  • Choline acetyltransferase (ChAT)
  • Excitotoxicity
  • Metabotropic glutamate receptor (mGluR)
  • N-methyl-D-aspartate (NMDA)
  • Neuroprotection
  • Retina

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Siliprandi, R., Lipartiti, M., Fadda, E., Arban, R., Kozikowski, A. P., & Manev, H. (1994). A derivative of a rigid glutamate analog protects the retina from excitotoxicity. NeuroReport, 5(10), 1227-1229.

A derivative of a rigid glutamate analog protects the retina from excitotoxicity. / Siliprandi, Renata; Lipartiti, Maria; Fadda, Emanuela; Arban, Roberto; Kozikowski, Alan P.; Manev, Hari.

In: NeuroReport, Vol. 5, No. 10, 1994, p. 1227-1229.

Research output: Contribution to journalArticle

Siliprandi, R, Lipartiti, M, Fadda, E, Arban, R, Kozikowski, AP & Manev, H 1994, 'A derivative of a rigid glutamate analog protects the retina from excitotoxicity', NeuroReport, vol. 5, no. 10, pp. 1227-1229.
Siliprandi R, Lipartiti M, Fadda E, Arban R, Kozikowski AP, Manev H. A derivative of a rigid glutamate analog protects the retina from excitotoxicity. NeuroReport. 1994;5(10):1227-1229.
Siliprandi, Renata ; Lipartiti, Maria ; Fadda, Emanuela ; Arban, Roberto ; Kozikowski, Alan P. ; Manev, Hari. / A derivative of a rigid glutamate analog protects the retina from excitotoxicity. In: NeuroReport. 1994 ; Vol. 5, No. 10. pp. 1227-1229.
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