A deletion map of the WAGR region on chromosome 11

M. Gessler, G. H. Thomas, P. Couillin, C. Junien, B. C. McGillivray, M. Hayden, G. Jaschek, G. A P Bruns

Research output: Contribution to journalArticle

Abstract

The WAGR (Wilms tumor, aniridia, genitourinary anomalies, and mental retardation) region has been assigned to chromosome 11p13 on the basis of overlapping constitutional deletions found in affected individuals. We have utilized 31 DNA probes which map to the WAGR deletion region, together with six reference loci and 13 WAGR-related deletions, to subdivide this area into 16 intervals. Specific intervals have been correlated with phenotypic features, leading to the identification of individual subregions for the aniridia and Wilms tumor loci. Delineation, by specific probes, of multiple intervals above and below the critical region and of five intervals within the overlap area provides a framework map for molecular characterization of WAGR gene loci and of deletion boundary regions.

Original languageEnglish (US)
Pages (from-to)486-495
Number of pages10
JournalAmerican Journal of Human Genetics
Volume44
Issue number4
StatePublished - 1989
Externally publishedYes

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Aniridia
Chromosomes, Human, Pair 11
Wilms Tumor
DNA Probes
Gene Deletion
Intellectual Disability
Chromosomes

ASJC Scopus subject areas

  • Genetics

Cite this

Gessler, M., Thomas, G. H., Couillin, P., Junien, C., McGillivray, B. C., Hayden, M., ... Bruns, G. A. P. (1989). A deletion map of the WAGR region on chromosome 11. American Journal of Human Genetics, 44(4), 486-495.

A deletion map of the WAGR region on chromosome 11. / Gessler, M.; Thomas, G. H.; Couillin, P.; Junien, C.; McGillivray, B. C.; Hayden, M.; Jaschek, G.; Bruns, G. A P.

In: American Journal of Human Genetics, Vol. 44, No. 4, 1989, p. 486-495.

Research output: Contribution to journalArticle

Gessler, M, Thomas, GH, Couillin, P, Junien, C, McGillivray, BC, Hayden, M, Jaschek, G & Bruns, GAP 1989, 'A deletion map of the WAGR region on chromosome 11', American Journal of Human Genetics, vol. 44, no. 4, pp. 486-495.
Gessler M, Thomas GH, Couillin P, Junien C, McGillivray BC, Hayden M et al. A deletion map of the WAGR region on chromosome 11. American Journal of Human Genetics. 1989;44(4):486-495.
Gessler, M. ; Thomas, G. H. ; Couillin, P. ; Junien, C. ; McGillivray, B. C. ; Hayden, M. ; Jaschek, G. ; Bruns, G. A P. / A deletion map of the WAGR region on chromosome 11. In: American Journal of Human Genetics. 1989 ; Vol. 44, No. 4. pp. 486-495.
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