@inproceedings{120f64243c7548579145a1c1d03db1b4,
title = "A deep-learning approach to translate between brain structure and functional connectivity",
abstract = "While the majority of exploratory approaches search for correlations among features of different modalities, indirect/nonlinear relations between structure and function have not yet been fully investigated. In this work, we employ a neural machine translation model [1] to relate two modalities: structural MRI (sMRI) spatial components and functional MRI (fMRI) brain states estimated using a dynamic connectivity model. We consider each of the modalities as different 'languages' of the same brain and fit a translation model to estimate a model for how structure influences function. Results identify multiple aligned aspects of brain structure and functional brain states showing significantly more or less alignment in the patient group as well as interesting links to other variables such as cognitive scores and symptom assessments. Our novel approach provides a new perspective on combining brain structure and function by incorporating indirect/nonlinear effects and enabling the algorithm to learn the interplay between structural and the functional networks.",
keywords = "deep learning, multimodal fusion, psychosis, schizophrenia",
author = "Calhoun, {Vince D.} and Amin, {Md Faijul} and Devon Hjelm and Eswar Damaraju and Plis, {Sergey M.}",
note = "Funding Information: This work was sponsored by NIH grants RO IEB00684I , RO IEB005846, ROlEB020407 and P20GMI03472 as well as NSF grant 1539067. Publisher Copyright: {\textcopyright} 2017 IEEE.; 2017 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2017 ; Conference date: 05-03-2017 Through 09-03-2017",
year = "2017",
month = jun,
day = "16",
doi = "10.1109/ICASSP.2017.7953339",
language = "English (US)",
series = "ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "6155--6159",
booktitle = "2017 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2017 - Proceedings",
}