N-[4-(β-D-Galactopyranosyl)-3-nitrobenzyloxycarbonyl]daunomycin was synthesized as a neutral prodrug of daunomycin. Although stable in 0.05 M phosphate buffer, pH 7.4 at 37°C, it was rapidly converted to daunomycin and 3-nitro-4-hydroxybenzyl alcohol under the same conditions in the presence of E. coli β-galactosidase. (C) 2000 Elsevier Science Ltd.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jun 19 2000|
- Gene therapy
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery