A cyanine based fluorophore emitting both single photon near-infrared fluorescence and two-photon deep red fluorescence in aqueous solution

Lu Wang, Jiefu Jin, Xishan Chen, Hai Hua Fan, Billy King Fai Li, Kok Wai Cheah, Ning Ding, Shenghong Ju, Wing Tak Wong, Cong Li

Research output: Contribution to journalArticle

Abstract

Optical imaging provides an indispensable way to locate tumors in their early stages with high sensitivity and signal to background ratio. A heptamethine cyanine based fluorophore that emits both single photon near-infrared fluorescence and two-photon deep red fluorescence under physiological conditions was developed. Linear and nonlinear photophysical properties of this fluorophore were investigated and it demonstrated the capability to label lysosomes in cancer cells. The advantages of this fluorophore, including tolerable cytotoxicity, high fluorescence quantum yield, and the ability to emit both near-infrared single photon fluorescence and deep red two photon fluorescence in aqueous solution, give it potential to be used in intra-operatively optical image-guided tumor excision followed by two-photon fluorescence microscopy biopsy analysis after a single administration.

Original languageEnglish (US)
Pages (from-to)5366-5370
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number28
DOIs
StatePublished - Jul 28 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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